PLK2

Polo-like kinase 2
Identifiers
Symbols	PLK2; SNK
External IDs	OMIM: 607023 MGI: 1099790 HomoloGene: 21317 GeneCards: PLK2 Gene
EC number	2.7.11.21
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • signal transducer activity • protein binding • ATP binding Biological process • mitotic cell cycle • signal transduction • positive regulation of I-kappaB kinase/NF-kappaB cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10769	20620
Ensembl	ENSG00000145632	ENSMUSG00000021701
UniProt	Q9NYY3	Q3TV29
RefSeq (mRNA)	NM_006622	NM_152804.2
RefSeq (protein)	NP_006613	NP_690017.2
Location (UCSC)	Chr 5: 57.75 – 57.76 Mb	Chr 13: 111.19 – 111.19 Mb
PubMed search	[1]	[2]

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division.[supplied by OMIM]

Further reading

• Kauselmann G, Weiler M, Wulff P, et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity.". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171621. 
• Ouyang B, Li W, Pan H, et al. (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.". Oncogene 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092. 
• Holtrich U, Wolf G, Yuan J, et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.". Oncogene 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900. 
• Liby K, Wu H, Ouyang B, et al. (2002). "Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase.". DNA Seq. 11 (6): 527–33. doi:10.3109/10425170109041337. PMID 11696980. 
• Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, et al. (2002). "Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells.". Biochem. Biophys. Res. Commun. 289 (2): 491–8. doi:10.1006/bbrc.2001.5993. PMID 11716500. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.". Mol. Cancer Res. 1 (5): 376–84. PMID 12651910. 
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. 
• Burns TF, Fei P, Scata KA, et al. (2003). "Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells.". Mol. Cell. Biol. 23 (16): 5556–71. doi:10.1128/MCB.23.16.5556-5571.2003. PMC 166320. PMID 12897130. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=166320. 
• Ma S, Charron J, Erikson RL (2003). "Role of Plk2 (Snk) in mouse development and cell proliferation.". Mol. Cell. Biol. 23 (19): 6936–43. doi:10.1128/MCB.23.19.6936-6943.2003. PMC 193943. PMID 12972611. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193943. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Yogosawa S, Hatakeyama S, Nakayama KI, et al. (2006). "Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.". J. Biol. Chem. 280 (50): 41619–27. doi:10.1074/jbc.M508397200. PMID 16203730. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Park YY, Kim SH, Kim YJ, et al. (2007). "Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma).". Biochem. Biophys. Res. Commun. 362 (1): 107–13. doi:10.1016/j.bbrc.2007.07.170. PMID 17706602. 
• Matthew EM, Yen TJ, Dicker DT, et al. (2007). "Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells.". Cell Cycle 6 (20): 2571–8. doi:10.4161/cc.6.20.5079. PMID 17912033.