PLK3

Polo-like kinase 3
Identifiers
Symbols	PLK3; CNK; FNK; PRK
External IDs	OMIM: 602913 MGI: 109604 HomoloGene: 20865 GeneCards: PLK3 Gene
EC number	2.7.11.21
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding Cellular component • membrane • dendrite Biological process • protein phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1263	12795
Ensembl	ENSG00000173846	ENSMUSG00000028680
UniProt	Q9H4B4	Q3U0L5
RefSeq (mRNA)	NM_004073	NM_013807.2
RefSeq (protein)	NP_004064	NP_038835.2
Location (UCSC)	Chr 1: 45.27 – 45.27 Mb	Chr 4: 116.8 – 116.81 Mb
PubMed search	[1]	[2]

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

Function

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.

Interactions

PLK3 has been shown to interact with CDC25C, CHEK2 and P53.

Further reading

• Li B, Ouyang B, Pan H et al (1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627. 
• Peng CY, Graves PR, Thoma RS et al (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID 9278512. 
• Ouyang B, Pan H, Lu L et al (1997). "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions". J. Biol. Chem. 272 (45): 28646–51. doi:10.1074/jbc.272.45.28646. PMID 9353331. 
• Kauselmann G, Weiler M, Wulff P et al (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171621. 
• Ouyang B, Li W, Pan H et al (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092. 
• Shieh SY, Ahn J, Tamai K et al (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites". Genes Dev. 14 (3): 289–300. PMC 316358. PMID 10673501. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316358. 
• Dai W, Li Y, Ouyang B et al (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer 27 (3): 332–6. doi:10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K. PMID 10679924. 
• Matsuoka S, Rotman G, Ogawa A et al (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389–94. doi:10.1073/pnas.190030497. PMC 27034. PMID 10973490. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27034. 
• Holtrich U, Wolf G, Yuan J et al (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900. 
• Bulavin DV, Higashimoto Y, Popoff IJ et al (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature 411 (6833): 102–7. doi:10.1038/35075107. PMID 11333986. 
• Xie S, Wu H, Wang Q et al (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930. 
• Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts". Oncogene 20 (46): 6784–93. doi:10.1038/sj.onc.1204883. PMID 11709713. 
• Ahn JY, Li X, Davis HL, Canman CE (2002). "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain". J. Biol. Chem. 277 (22): 19389–95. doi:10.1074/jbc.M200822200. PMID 11901158. 
• Sumara I, Vorlaufer E, Stukenberg PT et al (2002). "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase". Mol. Cell 9 (3): 515–25. doi:10.1016/S1097-2765(02)00473-2. PMID 11931760. 
• Wang Q, Xie S, Chen J et al (2002). "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity". Mol. Cell. Biol. 22 (10): 3450–9. doi:10.1128/MCB.22.10.3450-3459.2002. PMC 133784. PMID 11971976. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133784. 
• Bahassi el M, Conn CW, Myer DL et al (2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tsvetkov L, Xu X, Li J, Stern DF (2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody". J. Biol. Chem. 278 (10): 8468–75. doi:10.1074/jbc.M211202200. PMID 12493754. 
• Xie S, Wu H, Wang Q et al (2003). "Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2". Cell Cycle 1 (6): 424–9. doi:10.4161/cc.1.6.271. PMID 12548019. 
• Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation". Oncogene 23 (15): 2658–63. doi:10.1038/sj.onc.1207425. PMID 14968113.