PLK3

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Polo-like kinase 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PLK3 ; CNK; FNK; PRK
External IDs OMIM602913 MGI109604 HomoloGene20865 ChEMBL: 4897 GeneCards: PLK3 Gene
EC number 2.7.11.21
RNA expression pattern
PBB GE PLK3 204958 at tn.png
PBB GE PLK3 215462 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1263 12795
Ensembl ENSG00000173846 ENSMUSG00000028680
UniProt Q9H4B4 A2AE77
RefSeq (mRNA) NM_004073 NM_013807
RefSeq (protein) NP_004064 NP_038835
Location (UCSC) Chr 1:
45.27 – 45.27 Mb
Chr 4:
117.13 – 117.13 Mb
PubMed search [1] [2]

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.[1][2]

Function[edit]

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.[1]

Interactions[edit]

PLK3 has been shown to interact with CDC25C,[3] CHEK2[4] and P53.[4][5]

References[edit]

  1. ^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)". 
  2. ^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627. 
  3. ^ Ouyang, B; Li W; Pan H; Meadows J; Hoffmann I; Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene (ENGLAND) 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. ISSN 0950-9232. PMID 10557092. 
  4. ^ a b Bahassi, El Mustapha; Conn Christopher W; Myer David L; Hennigan Robert F; McGowan Clare H; Sanchez Yolanda; Stambrook Peter J (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene (England) 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. ISSN 0950-9232. PMID 12242661. 
  5. ^ Xie, S; Wu H; Wang Q; Cogswell J P; Husain I; Conn C; Stambrook P; Jhanwar-Uniyal M; Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. (United States) 276 (46): 43305–12. doi:10.1074/jbc.M106050200. ISSN 0021-9258. PMID 11551930. 

Further reading[edit]