PLK4

Polo-like kinase 4
PDB rendering based on 1mby.
Available structures PDB 1mby
Identifiers
Symbols	PLK4; SAK; STK18
External IDs	OMIM: 605031 MGI: 101783 HomoloGene: 7962 GeneCards: PLK4 Gene
EC number	2.7.11.21
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein tyrosine kinase activity • protein binding • ATP binding Cellular component • nucleus • nucleolus • cytoplasm • centrosome • centriole • cytosol • cytoskeleton • cleavage furrow Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • protein phosphorylation • positive regulation of centriole replication • trophoblast giant cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10733	20873
Ensembl	ENSG00000142731	ENSMUSG00000025758
UniProt	O00444	Q3UVA3
RefSeq (mRNA)	NM_001190799.1	NM_011495.2
RefSeq (protein)	NP_001177728.1	NP_035625.2
Location (UCSC)	Chr 4: 128.8 – 128.82 Mb	Chr 3: 40.6 – 40.62 Mb
PubMed search	[1]	[2]

Serine/threonine-protein kinase PLK4 is an enzyme that in humans is encoded by the PLK4 gene.

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle.

Interactions

PLK4 has been shown to interact with Stratifin.

Further reading

• Kleylein-Sohn J, Westendorf J, Le Clech M et al (2007). "Plk4-induced centriole biogenesis in human cells". Dev. Cell 13 (2): 190–202. doi:10.1016/j.devcel.2007.07.002. PMID 17681131. 
• Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L et al (2006). "SAK/PLK4 is required for centriole duplication and flagella development". Curr. Biol. 15 (24): 2199–207. doi:10.1016/j.cub.2005.11.042. PMID 16326102. 
• Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA (2006). "The Polo kinase Plk4 functions in centriole duplication". Nat. Cell Biol. 7 (11): 1140–6. doi:10.1038/ncb1320. PMID 16244668. 
• Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Li J, Tan M, Li L et al (2005). "SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing". Neoplasia 7 (4): 312–23. doi:10.1593/neo.04325. PMC 1501148. PMID 15967108. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1501148. 
• Barrios-Rodiles M, Brown KR, Ozdamar B et al (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Suzuki Y, Yamashita R, Shirota M et al (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Macmillan JC, Hudson JW, Bull S et al (2002). "Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer". Ann. Surg. Oncol. 8 (9): 729–40. doi:10.1007/s10434-001-0729-6. PMID 11597015. 
• Yamashita Y, Kajigaya S, Yoshida K et al (2001). "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase". J. Biol. Chem. 276 (42): 39012–20. doi:10.1074/jbc.M106249200. PMID 11489907. 
• Hudson JW, Chen L, Fode C et al (2000). "Sak kinase gene structure and transcriptional regulation". Gene 241 (1): 65–73. doi:10.1016/S0378-1119(99)00467-9. PMID 10607900. 
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.