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PLM may refer to:
- Chemins de fer de Paris à Lyon et à la Méditerranée (PLM), a French railway company
- Pamantasan ng Lungsod ng Maynila, the University of the City of Manila
- Partido Lakas ng Masa, a Philippine political party
- Partido Liberal Mexicano, a pre-1910 Revolution Mexican political party
- Periodic Limb Movement Disorder
- PL/M, a computer programming language
- Plant lifecycle management, the process of managing an industrial facility's data and information throughout its lifetime
- Polarized Light Microscopy, a form of microscopy
- Pour le Merite, Order of Imperial Germany, a blue Maltese cross award medal.
- Product lifecycle management, the process of managing the entire lifecycle of a product
- Product life cycle management (marketing)
- Sultan Mahmud Badaruddin II Airport (IATA airport code: PLM), in Palembang, Indonesia
- Indonesian for perahu layar motor, a traditional type of lambo (boat).
- Planar Lipid Membranes, a kind of Lipid bilayer
- A Payload Module on a satellite or spacecraft, such as the SOHO Payload Module (PLM)
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