PLSCR1

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Phospholipid scramblase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PLSCR1 ; MMTRA1B
External IDs OMIM604170 MGI893575 HomoloGene41418 GeneCards: PLSCR1 Gene
RNA expression pattern
PBB GE PLSCR1 202446 s at tn.png
PBB GE PLSCR1 202430 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5359 22038
Ensembl ENSG00000188313 ENSMUSG00000032369
UniProt O15162 Q9JJ00
RefSeq (mRNA) NM_021105 NM_011636
RefSeq (protein) NP_066928 NP_035766
Location (UCSC) Chr 3:
146.23 – 146.26 Mb
Chr 9:
92.25 – 92.27 Mb
PubMed search [1] [2]

Phospholipid scramblase 1 is an enzyme that in humans is encoded by the PLSCR1 gene.[1][2]


See also[edit]

Interactions[edit]

PLSCR1 has been shown to interact with NEU4,[3] SLPI,[4] SHC1,[5][6] CPSF6,[3] Epidermal growth factor receptor[6] and TFG.[3]

References[edit]

  1. ^ Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ (August 1997). "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids". J Biol Chem 272 (29): 18240–4. doi:10.1074/jbc.272.29.18240. PMID 9218461. 
  2. ^ "Entrez Gene: PLSCR1 phospholipid scramblase 1". 
  3. ^ a b c Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Tseng, C C; Tseng C P (June 2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. (NETHERLANDS) 475 (3): 232–6. doi:10.1016/S0014-5793(00)01700-2. ISSN 0014-5793. PMID 10869562. 
  5. ^ Nanjundan, Meera; Sun Jun; Zhao Ji; Zhou Quansheng; Sims Peter J; Wiedmer Therese (September 2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. (United States) 278 (39): 37413–8. doi:10.1074/jbc.M306182200. ISSN 0021-9258. PMID 12871937. 
  6. ^ a b Sun, Jun; Nanjundan Meera; Pike Linda J; Wiedmer Therese; Sims Peter J (May 2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry (United States) 41 (20): 6338–45. doi:10.1021/bi025610l. ISSN 0006-2960. PMID 12009895. 

Further reading[edit]

  • Bassé F, Stout JG, Sims PJ, Wiedmer T (1996). "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.". J. Biol. Chem. 271 (29): 17205–10. doi:10.1074/jbc.271.29.17205. PMID 8663431. 
  • Zhou Q, Sims PJ, Wiedmer T (1998). "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.". Biochemistry 37 (8): 2356–60. doi:10.1021/bi972625o. PMID 9485382. 
  • Zhao J, Zhou Q, Wiedmer T, Sims PJ (1998). "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.". Biochemistry 37 (18): 6361–6. doi:10.1021/bi980218m. PMID 9572851. 
  • Kasukabe T, Kobayashi H, Kaneko Y et al. (1998). "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene". Biochem. Biophys. Res. Commun. 249 (2): 449–55. doi:10.1006/bbrc.1998.9190. PMID 9712717. 
  • Zhou Q, Zhao J, Al-Zoghaibi F et al. (2000). "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha". Blood 95 (8): 2593–9. PMID 10753839. 
  • Frasch SC, Henson PM, Kailey JM et al. (2000). "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta". J. Biol. Chem. 275 (30): 23065–73. doi:10.1074/jbc.M003116200. PMID 10770950. 
  • Tseng CC, Tseng CP (2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. doi:10.1016/S0014-5793(00)01700-2. PMID 10869562. 
  • Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526. 
  • Sun J, Zhao J, Schwartz MA et al. (2001). "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1". J. Biol. Chem. 276 (31): 28984–90. doi:10.1074/jbc.M102505200. PMID 11390389. 
  • Silverman RH, Halloum A, Zhou A et al. (2002). "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1". Cancer Res. 62 (2): 397–402. PMID 11809687. 
  • Sun J, Nanjundan M, Pike LJ et al. (2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry 41 (20): 6338–45. doi:10.1021/bi025610l. PMID 12009895. 
  • Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1". Blood 99 (11): 4030–8. doi:10.1182/blood-2001-12-0271. PMID 12010804. 
  • Xu YC, Wu RF, Gu Y et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963. 
  • Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y et al. (2002). "Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes". Exp. Hematol. 30 (5): 421–9. doi:10.1016/S0301-472X(02)00779-8. PMID 12031648. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Wiedmer T, Zhao J, Nanjundan M, Sims PJ (2003). "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane". Biochemistry 42 (5): 1227–33. doi:10.1021/bi026679w. PMID 12564925. 
  • Kametaka S, Shibata M, Moroe K et al. (2003). "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))". J. Biol. Chem. 278 (17): 15239–45. doi:10.1074/jbc.M208611200. PMID 12586838. 
  • Rami A, Sims J, Botez G, Winckler J (2003). "Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia". Neurochem. Int. 43 (1): 79–87. doi:10.1016/S0197-0186(02)00194-8. PMID 12605885. 
  • Nanjundan M, Sun J, Zhao J et al. (2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. doi:10.1074/jbc.M306182200. PMID 12871937.