PLXNB1

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Plexin B1
Protein PLXNB1 PDB 2JPH.png
Rendering based on PDB 2JPH.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PLXNB1 ; PLEXIN-B1; PLXN5; SEP
External IDs OMIM601053 MGI2154238 HomoloGene130508 GeneCards: PLXNB1 Gene
RNA expression pattern
PBB GE PLXNB1 215807 s at tn.png
PBB GE PLXNB1 215668 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5364 235611
Ensembl ENSG00000164050 ENSMUSG00000053646
UniProt O43157 Q8CJH3
RefSeq (mRNA) NM_001130082 NM_172775
RefSeq (protein) NP_001123554 NP_766363
Location (UCSC) Chr 3:
48.45 – 48.47 Mb
Chr 9:
109.1 – 109.12 Mb
PubMed search [1] [2]

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.[1][2][3]

Function[edit]

Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins.[4] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration.[5]

Interactions[edit]

PLXNB1 has been shown to interact with ARHGEF12,[6] Rnd1[7] and ARHGEF11.[6][7][8][9]

References[edit]

  1. ^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S et al. (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci U S A 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614. 
  2. ^ Vikis H, Li W, He Z, Guan K (Nov 2000). "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner". Proc Natl Acad Sci U S A 97 (23): 12457–62. doi:10.1073/pnas.220421797. PMC 18785. PMID 11035813. 
  3. ^ "Entrez Gene: PLXNB1 plexin B1". 
  4. ^ Driessens M, Olivo C, Nagata K, Inagaki M, Collard J (Oct 9, 2002). "B plexins activate Rho through PDZ-RhoGEF.". FEBS Letters 529 (2-3): 168–72. doi:10.1016/s0014-5793(02)03323-9. PMID 12372594. 
  5. ^ Basile J, Afkhami T, Gutkind J (Aug 2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.". Molecular and Cellular Biology 25 (16): 6889–98. doi:10.1128/mcb.25.16.6889-6898.2005. PMC 1190270. PMID 16055703. 
  6. ^ a b Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M et al. (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504. 
  7. ^ a b Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". J. Biol. Chem. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235. 
  8. ^ Perrot V, Vazquez-Prado J, Gutkind J (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458. 
  9. ^ Swiercz J, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608. 

Further reading[edit]