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Plexin B2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLXNB2 ; MM1; Nbla00445; PLEXB2; dJ402G11.3
External IDs OMIM604293 MGI2154239 HomoloGene66630 GeneCards: PLXNB2 Gene
RNA expression pattern
PBB GE PLXNB2 208890 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23654 140570
Ensembl ENSG00000196576 ENSMUSG00000036606
UniProt O15031 B2RXS4
RefSeq (mRNA) NM_012401 NM_001159521
RefSeq (protein) NP_036533 NP_001152993
Location (UCSC) Chr 22:
50.71 – 50.75 Mb
Chr 15:
89.16 – 89.17 Mb
PubMed search [1] [2]

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.[1][2][3]

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM][3]


PLXNB2 has been shown to interact with ARHGEF11.[2][4]


  1. ^ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. 
  2. ^ a b Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458. 
  3. ^ a b "Entrez Gene: PLXNB2 plexin B2". 
  4. ^ Swiercz, Jakub M; Kuner Rohini; Behrens Jürgen; Offermanns Stefan (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron (United States) 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. ISSN 0896-6273. PMID 12123608. 

Further reading[edit]