PMM1

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Phosphomannomutase 1
Protein PMM1 PDB 2fuc.png
PDB rendering based on 2fuc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PMM1 ; Sec53
External IDs OMIM601786 MGI1353418 HomoloGene90898 GeneCards: PMM1 Gene
EC number 5.4.2.8
RNA expression pattern
PBB GE PMM1 203467 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5372 29858
Ensembl ENSG00000100417 ENSMUSG00000022474
UniProt Q92871 O35621
RefSeq (mRNA) NM_002676 NM_013872
RefSeq (protein) NP_002667 NP_038900
Location (UCSC) Chr 22:
41.97 – 41.99 Mb
Chr 15:
81.95 – 81.96 Mb
PubMed search [1] [2]

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.[1][2][3]

Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins.[3]

References[edit]

  1. ^ Matthijs G, Schollen E, Pirard M, Budarf ML, Van Schaftingen E, Cassiman JJ (Jun 1997). "PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13". Genomics 40 (1): 41–7. doi:10.1006/geno.1996.4536. PMID 9070917. 
  2. ^ Pirard M, Collet JF, Matthijs G, Van Schaftingen E (Sep 1997). "Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells". FEBS Lett 411 (2-3): 251–4. doi:10.1016/S0014-5793(97)00704-7. PMID 9271215. 
  3. ^ a b "Entrez Gene: PMM1 phosphomannomutase 1". 

Further reading[edit]