PMS1

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PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
Protein PMS1 PDB 2cs1.png
PDB rendering based on 2cs1.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PMS1 ; HNPCC3; PMSL1; hPMS1
External IDs OMIM600258 MGI1202302 HomoloGene449 GeneCards: PMS1 Gene
RNA expression pattern
PBB GE PMS1 213677 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5378 227099
Ensembl ENSG00000064933 ENSMUSG00000026098
UniProt P54277 Q8K119
RefSeq (mRNA) NM_000534 NM_153556
RefSeq (protein) NP_000525 NP_705784
Location (UCSC) Chr 2:
190.65 – 190.74 Mb
Chr 1:
53.19 – 53.3 Mb
PubMed search [1] [2]

PMS1 protein homolog 1 is a protein that in humans is encoded by the PMS1 gene.[1][2]

The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.[2]

References[edit]

  1. ^ Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, Ruben SM, Rosen CA, Haseltine WA, Fleischmann RD (Sep 1994). "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer". Nature 371 (6492): 75–80. doi:10.1038/371075a0. PMID 8072530. 
  2. ^ a b "Entrez Gene: PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)". 

Further reading[edit]