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Polynucleotide kinase 3'-phosphatase
Protein PNKP PDB 2brf.png
PDB rendering based on 2brf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PNKP ; EIEE10; MCSZ; PNK
External IDs OMIM605610 MGI1891698 HomoloGene5247 GeneCards: PNKP Gene
EC number,
RNA expression pattern
PBB GE PNKP 218961 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11284 59047
Ensembl ENSG00000039650 ENSMUSG00000002963
UniProt Q96T60 Q9JLV6
RefSeq (mRNA) NM_007254 NM_001290764
RefSeq (protein) NP_009185 NP_001277693
Location (UCSC) Chr 19:
50.36 – 50.37 Mb
Chr 7:
44.86 – 44.86 Mb
PubMed search [1] [2]

Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene.[1][2][3]


PNKP has been shown to interact with DNA polymerase beta[4] and XRCC1.[4][5]


  1. ^ Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW et al. (September 1999). "Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage". J. Biol. Chem. 274 (34): 24176–86. doi:10.1074/jbc.274.34.24176. PMID 10446192. 
  2. ^ Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J et al. (September 1999). "Molecular characterization of a human DNA kinase". J. Biol. Chem. 274 (34): 24187–94. doi:10.1074/jbc.274.34.24187. PMID 10446193. 
  3. ^ "Entrez Gene: PNKP polynucleotide kinase 3'-phosphatase". 
  4. ^ a b Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD et al. (January 2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell 104 (1): 107–17. doi:10.1016/S0092-8674(01)00195-7. PMID 11163244. 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]