PNKP

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Polynucleotide kinase 3'-phosphatase
Protein PNKP PDB 2brf.png
PDB rendering based on 2brf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PNKP ; EIEE10; MCSZ; PNK
External IDs OMIM605610 MGI1891698 HomoloGene5247 GeneCards: PNKP Gene
EC number 2.7.1.78, 3.1.3.32
RNA expression pattern
PBB GE PNKP 218961 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11284 59047
Ensembl ENSG00000039650 ENSMUSG00000002963
UniProt Q96T60 Q9JLV6
RefSeq (mRNA) NM_007254 NM_001290764
RefSeq (protein) NP_009185 NP_001277693
Location (UCSC) Chr 19:
50.36 – 50.37 Mb
Chr 7:
44.86 – 44.86 Mb
PubMed search [1] [2]

Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene.[1][2][3]


Interactions[edit]

PNKP has been shown to interact with DNA polymerase beta[4] and XRCC1.[4][5]

References[edit]

  1. ^ Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD (September 1999). "Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage". J Biol Chem 274 (34): 24176–24186. doi:10.1074/jbc.274.34.24176. PMID 10446192. 
  2. ^ Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M (September 1999). "Molecular characterization of a human DNA kinase". J Biol Chem 274 (34): 24187–24194. doi:10.1074/jbc.274.34.24187. PMID 10446193. 
  3. ^ "Entrez Gene: PNKP polynucleotide kinase 3'-phosphatase". 
  4. ^ a b Whitehouse, C J; Taylor R M; Thistlethwaite A; Zhang H; Karimi-Busheri F; Lasko D D; Weinfeld M; Caldecott K W (January 2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell (United States) 104 (1): 107–117. doi:10.1016/S0092-8674(01)00195-7. ISSN 0092-8674. PMID 11163244. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]