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Proline-rich nuclear receptor coactivator 1
Symbols PNRC1 ; B4-2; PNAS-145; PROL2; PRR2
External IDs OMIM606714 MGI1917838 HomoloGene4960 GeneCards: PNRC1 Gene
RNA expression pattern
PBB GE PNRC1 209034 at tn.png
More reference expression data
Species Human Mouse
Entrez 10957 108767
Ensembl ENSG00000146278 ENSMUSG00000040128
UniProt Q12796 Q3TWH3
RefSeq (mRNA) NM_006813 NM_001033225
RefSeq (protein) NP_006804 NP_001028397
Location (UCSC) Chr 6:
89.79 – 89.79 Mb
Chr 4:
33.25 – 33.29 Mb
PubMed search [1] [2]

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[1][2]


PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[3][4] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[4]


  1. ^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250. 
  2. ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1". 
  3. ^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/me.14.7.986. PMID 10894149. 
  4. ^ a b Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675. 

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