PNRC1

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Proline-rich nuclear receptor coactivator 1
Identifiers
Symbols PNRC1 ; B4-2; PNAS-145; PROL2; PRR2
External IDs OMIM606714 MGI1917838 HomoloGene4960 GeneCards: PNRC1 Gene
RNA expression pattern
PBB GE PNRC1 209034 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10957 108767
Ensembl ENSG00000146278 ENSMUSG00000040128
UniProt Q12796 Q3TWH3
RefSeq (mRNA) NM_006813 NM_001033225
RefSeq (protein) NP_006804 NP_001028397
Location (UCSC) Chr 6:
89.79 – 89.79 Mb
Chr 4:
33.25 – 33.29 Mb
PubMed search [1] [2]

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[1][2]

Function[edit]

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[3][4] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[4]

References[edit]

  1. ^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250. 
  2. ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1". 
  3. ^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/me.14.7.986. PMID 10894149. 
  4. ^ a b Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675. 

Further reading[edit]

External links[edit]