PNU-181731

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PNU-181731
PNU-181731 structure.png
Systematic (IUPAC) name
2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole
Clinical data
Legal status
?
Identifiers
CAS number 364344-56-9 YesY
ATC code ?
PubChem CID 9794092
Chemical data
Formula C12H14N2 
Mol. mass 186.25 g/mol

PNU-181731 is a drug which acts as an agonist at serotonin 5-HT2 receptors,[1][2] with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM. It has anxiolytic effects in animal studies with around one tenth the potency of alprazolam and no significant ataxia or other side effects noted.[3]

See also[edit]

References[edit]

  1. ^ Michael D Ennis et al. 2,3,4,5-Tetrahydro-1H-[1,4diazepino[1,7-a]indole compounds. US Patent 6734301, Priority date March 14, 2000]
  2. ^ Junya Shirai et al. Fused heterocyclic compound and use thereof. US Patent 8158617, Priority date May 16, 2006
  3. ^ Ennis, M. D.; Hoffman, R. L.; Ghazal, N. B.; Olson, R. M.; Knauer, C. S.; Chio, C. L.; Hyslop, D. K.; Campbell, J. E.; Fitzgerald, L. W.; Nichols, N. F.; Svensson, K. A.; McCall, R. B.; Haber, C. L.; Kagey, M. L.; Dinh, D. M. (2003). "2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-\1,4]diazepino\1,7-a]indoles: New templates for 5-HT2C agonists". Bioorganic & Medicinal Chemistry Letters 13 (14): 2369–72. doi:10.1016/S0960-894X(03)00403-7. PMID 12824036.  edit