PNU-22394

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PNU-22394
PNU-22394 structure.png
Systematic (IUPAC) name
6-Methyl-1,2,3,4,5,6-hexahydro-azepino[4,5-b]indole
Clinical data
Legal status ?
Identifiers
CAS number 15923-78-1 YesY
ATC code ?
PubChem CID 27559
ChEMBL CHEMBL6557 N
Chemical data
Formula C13H16N2 
Mol. mass 200.279 g/mol
 N (what is this?)  (verify)

PNU-22394 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for 5-HT2A and 5-HT2C and slightly weaker at 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B. It has anorectic effects in both animal studies and human trials,[1][2] along with "Pro-Cognitive Properties",[3] although it has never been developed for medical use.


See also[edit]

References[edit]

  1. ^ McCall, R. B.; Franklin, S. R.; Hyslop, D. K.; Knauer, C. S.; Chio, C. L.; Haber, C. L.; Fitzgerald, L. W. (2001). PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans (Online). Society for Neuroscience 27 (309.2). Presentation Number 309.2. Convention Center Exhibit Hall, Poster Board TT-45, San Diego, CA: Society for Neuroscience Abstracts. Retrieved 18 July 2014. 
  2. ^ Garfield AS, Heisler LK (2009). "Pharmacological targeting of the serotonergic system for the treatment of obesity". The Journal of Physiology 587 (1): 49–60. doi:10.1113/jphysiol.2008.164152. PMC 2670022. 
  3. ^ Jensen, Anders A.; Plath, Niels; Pedersen, Martin Holst Friborg; Isberg, Vignir et al. (2013). "Design, Synthesis, and Pharmacological Characterization of N- and O-Substituted 5,6,7,8-Tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol Analogues: Novel 5-HT2A/5-HT2C Receptor Agonists with Pro-Cognitive Properties". Journal of Medicinal Chemistry 56 (3): 1211–1227. doi:10.1021/jm301656h. ISSN 0022-2623.