POLD2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Polymerase (DNA directed), delta 2, accessory subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol POLD2
External IDs OMIM600815 MGI1097163 HomoloGene4538 ChEMBL: 2763 GeneCards: POLD2 Gene
EC number 2.7.7.7
RNA expression pattern
PBB GE POLD2 201115 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5425 18972
Ensembl ENSG00000106628 ENSMUSG00000020471
UniProt P49005 O35654
RefSeq (mRNA) NM_001127218 NM_008894
RefSeq (protein) NP_001120690 NP_032920
Location (UCSC) Chr 7:
44.15 – 44.16 Mb
Chr 11:
5.87 – 5.88 Mb
PubMed search [1] [2]

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.[1][2] It is a component of the DNA polymerase delta complex.


Interactions[edit]

POLD2 has been shown to interact with PCNA.[3]

References[edit]

  1. ^ Zhang J, Tan CK, McMullen B, Downey KM, So AG (Feb 1996). "Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2)". Genomics 29 (1): 179–86. doi:10.1006/geno.1995.1229. PMID 8530069. 
  2. ^ "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa". 
  3. ^ Lu, Xiaoqing; Tan Cheng-Keat; Zhou Jin-Qiu; You Min; Carastro L Michael; Downey Kathleen M; So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. (United States) 277 (27): 24340–5. doi:10.1074/jbc.M200065200. ISSN 0021-9258. PMID 11986310. 

Further reading[edit]