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Polymerase (DNA-directed), delta 3, accessory subunit
PDB 1u76 EBI.jpg
Rendering of POLD3 from PDB 1U76
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols POLD3 ; P66; P68; PPP1R128
External IDs OMIM611415 MGI1915217 HomoloGene38202 ChEMBL: 2260 GeneCards: POLD3 Gene
RNA expression pattern
PBB GE POLD3 212836 at tn.png
More reference expression data
Species Human Mouse
Entrez 10714 67967
Ensembl ENSG00000077514 ENSMUSG00000030726
UniProt Q15054 Q9EQ28
RefSeq (mRNA) NM_006591 NM_133692
RefSeq (protein) NP_006582 NP_598453
Location (UCSC) Chr 11:
74.2 – 74.38 Mb
Chr 7:
100.08 – 100.12 Mb
PubMed search [1] [2]

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.[1][2] It is a component of the DNA polymerase delta complex.


POLD3 has been shown to interact with PCNA.[3][4]


  1. ^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083. 
  2. ^ "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit". 
  3. ^ Ducoux, M; Urbach S; Baldacci G; Hübscher U; Koundrioukoff S; Christensen J; Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. (United States) 276 (52): 49258–66. doi:10.1074/jbc.M106990200. ISSN 0021-9258. PMID 11595739. 
  4. ^ Ohta, Satoshi; Shiomi Yasushi; Sugimoto Katsunori; Obuse Chikashi; Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. doi:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929. 

Further reading[edit]