POLD3

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Polymerase (DNA-directed), delta 3, accessory subunit
PDB 1u76 EBI.jpg
Rendering of POLD3 from PDB 1U76
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols POLD3 ; P66; P68; PPP1R128
External IDs OMIM611415 MGI1915217 HomoloGene38202 ChEMBL: 2260 GeneCards: POLD3 Gene
RNA expression pattern
PBB GE POLD3 212836 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10714 67967
Ensembl ENSG00000077514 ENSMUSG00000030726
UniProt Q15054 Q9EQ28
RefSeq (mRNA) NM_006591 NM_133692
RefSeq (protein) NP_006582 NP_598453
Location (UCSC) Chr 11:
74.2 – 74.38 Mb
Chr 7:
100.08 – 100.12 Mb
PubMed search [1] [2]

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.[1][2] It is a component of the DNA polymerase delta complex.


Interactions[edit]

POLD3 has been shown to interact with PCNA.[3][4]

References[edit]

  1. ^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083. 
  2. ^ "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit". 
  3. ^ Ducoux, M; Urbach S; Baldacci G; Hübscher U; Koundrioukoff S; Christensen J; Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. (United States) 276 (52): 49258–66. doi:10.1074/jbc.M106990200. ISSN 0021-9258. PMID 11595739. 
  4. ^ Ohta, Satoshi; Shiomi Yasushi; Sugimoto Katsunori; Obuse Chikashi; Tsurimoto Toshiki (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. (United States) 277 (43): 40362–7. doi:10.1074/jbc.M206194200. ISSN 0021-9258. PMID 12171929. 

Further reading[edit]