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Polymerase (DNA-directed), delta interacting protein 3
Symbols POLDIP3 ; PDIP46; SKAR
External IDs OMIM611520 MGI1921076 HomoloGene13007 GeneCards: POLDIP3 Gene
RNA expression pattern
PBB GE POLDIP3 210583 at tn.png
PBB GE POLDIP3 210584 s at tn.png
PBB GE POLDIP3 212100 s at tn.png
More reference expression data
Species Human Mouse
Entrez 84271 73826
Ensembl ENSG00000100227 ENSMUSG00000041815
UniProt Q9BY77 Q8BG81
RefSeq (mRNA) NM_001278657 NM_178627
RefSeq (protein) NP_001265586 NP_848742
Location (UCSC) Chr 22:
42.98 – 43.01 Mb
Chr 15:
83.13 – 83.15 Mb
PubMed search [1] [2]

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.[1][2]

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[2]


POLDIP3 has been shown to interact with P70-S6 Kinase 1.[3]


  1. ^ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211. 
  2. ^ a b "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3". 
  3. ^ Richardson, Celeste J; Bröenstrup Mark; Fingar Diane C; Jülich Kristina; Ballif Bryan A; Gygi Steven; Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. (England) 14 (17): 1540–9. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740. 

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