From Wikipedia, the free encyclopedia
Jump to: navigation, search
Polymerase (DNA directed), epsilon 2, accessory subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols POLE2 ; DPE2
External IDs OMIM602670 MGI1197514 HomoloGene2015 GeneCards: POLE2 Gene
EC number
RNA expression pattern
PBB GE POLE2 205909 at tn.png
More reference expression data
Species Human Mouse
Entrez 5427 18974
Ensembl ENSG00000100479 ENSMUSG00000020974
UniProt P56282 O54956
RefSeq (mRNA) NM_001197330 NM_011133
RefSeq (protein) NP_001184259 NP_035263
Location (UCSC) Chr 14:
50.11 – 50.16 Mb
Chr 12:
69.2 – 69.23 Mb
PubMed search [1] [2]

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.[1][2][3]


POLE2 has been shown to interact with SAP18.[4]


  1. ^ Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441. 
  2. ^ Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964. 
  3. ^ "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)". 
  4. ^ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158. 

Further reading[edit]