POLG2

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Polymerase (DNA directed), gamma 2, accessory subunit
Protein POLG2 PDB 2g4c.png
PDB rendering based on 2g4c.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols POLG2 ; HP55; MTPOLB; PEOA4; POLB; POLG-BETA; POLGB
External IDs OMIM604983 MGI1354947 HomoloGene5221 GeneCards: POLG2 Gene
EC number 2.7.7.7
RNA expression pattern
PBB GE POLG2 205811 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11232 50776
Ensembl ENSG00000256525 ENSMUSG00000020718
UniProt Q9UHN1 Q9QZM2
RefSeq (mRNA) NM_007215 NM_015810
RefSeq (protein) NP_009146 NP_056625
Location (UCSC) Chr 17:
62.47 – 62.49 Mb
Chr 11:
106.77 – 106.78 Mb
PubMed search [1] [2]

DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene. [1][2][3]


References[edit]

  1. ^ Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem 272 (21): 13640–6. doi:10.1074/jbc.272.21.13640. PMID 9153213. 
  2. ^ "Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit". 
  3. ^ Lim, SE, Longley, MJ, Copeland, WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893. 

Further reading[edit]