POLQ
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| Polymerase (DNA directed), theta | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | POLQ; DKFZp781A0112; POLH; PRO0327 | ||||||||||||
| External IDs | OMIM: 604419 MGI: 2155399 HomoloGene: 32727 GeneCards: POLQ Gene | ||||||||||||
| EC number | 2.7.7.7 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10721 | 77782 | |||||||||||
| Ensembl | ENSG00000051341 | ENSMUSG00000034206 | |||||||||||
| UniProt | O75417 | n/a | |||||||||||
| RefSeq (mRNA) | NM_199420 | NM_029977 | |||||||||||
| RefSeq (protein) | NP_955452 | NP_084253 | |||||||||||
| Location (UCSC) | Chr 3: 121.15 – 121.27 Mb |
Chr 16: 37.01 – 37.1 Mb |
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| PubMed search | [1] | [2] | |||||||||||
DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene.[1][2]
[edit] References
- ^ Sharief FS, Vojta PJ, Ropp PA, Copeland WC (Aug 1999). "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase". Genomics 59 (1): 90–6. doi:10.1006/geno.1999.5843. PMID 10395804.
- ^ "Entrez Gene: POLQ polymerase (DNA directed), theta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10721.
[edit] Further reading
- Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
- Maga G, Shevelev I, Ramadan K, et al. (2002). "DNA polymerase theta purified from human cells is a high-fidelity enzyme.". J. Mol. Biol. 319 (2): 359–69. doi:10.1016/S0022-2836(02)00325-X. PMID 12051913.
- Seki M, Marini F, Wood RD (2003). "POLQ (Pol θ), a DNA polymerase and DNA-dependent ATPase in human cells". Nucleic Acids Res. 31 (21): 6117–26. doi:10.1093/nar/gkg814. PMC 275456. PMID 14576298. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275456.
- Kawamura K, Bahar R, Seimiya M, et al. (2004). "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers". Int. J. Cancer 109 (1): 9–16. doi:10.1002/ijc.11666. PMID 14735462.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
- Seki M, Masutani C, Yang LW, et al. (2005). "High-efficiency bypass of DNA damage by human DNA polymerase Q". EMBO J. 23 (22): 4484–94. doi:10.1038/sj.emboj.7600424. PMC 526458. PMID 15496986. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=526458.
- Chiapperino D, Cai M, Sayer JM, et al. (2006). "Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene". J. Biol. Chem. 280 (48): 39684–92. doi:10.1074/jbc.M508008200. PMID 16188888.
- Zan H, Shima N, Xu Z, et al. (2005). "The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation". EMBO J. 24 (21): 3757–69. doi:10.1038/sj.emboj.7600833. PMC 1276717. PMID 16222339. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1276717.
- Cruet-Hennequart S, Coyne S, Glynn MT, et al. (2006). "UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK". DNA Repair (Amst.) 5 (4): 491–504. doi:10.1016/j.dnarep.2006.01.008. PMID 16520097.
- Chen YW, Cleaver JE, Hanaoka F, et al. (2006). "A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents". Mol. Cancer Res. 4 (4): 257–65. doi:10.1158/1541-7786.MCR-05-0118. PMID 16603639.
- Yuasa MS, Masutani C, Hirano A, et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest". Genes Cells 11 (7): 731–44. doi:10.1111/j.1365-2443.2006.00974.x. PMID 16824193.
- Choi JY, Stover JS, Angel KC, et al. (2006). "Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site". J. Biol. Chem. 281 (35): 25297–306. doi:10.1074/jbc.M605699200. PMID 16835218.
- Kino K, Ito N, Sugasawa K, et al. (2007). "Translesion synthesis by human DNA polymerase eta across oxidative products of guanine". Nucleic Acids Symp Ser (Oxf) 48 (48): 171–2. doi:10.1093/nass/48.1.171. PMID 17150533.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
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