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Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Symbols POLR2E ; RPABC1; RPB5; XAP4; hRPB25; hsRPB5
External IDs OMIM180664 MGI1913670 HomoloGene2018 GeneCards: POLR2E Gene
EC number
RNA expression pattern
PBB GE POLR2E 217854 s at tn.png
PBB GE POLR2E 213887 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5434 66420
Ensembl ENSG00000099817 ENSMUSG00000004667
UniProt P19388 Q80UW8
RefSeq (mRNA) NM_002695 NM_025554
RefSeq (protein) NP_002686 NP_079830
Location (UCSC) Chr 19:
1.09 – 1.1 Mb
Chr 10:
80.04 – 80.04 Mb
PubMed search [1] [2]

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.[1]

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.[2]


POLR2E has been shown to interact with TAF15,[3] POLR2C,[4] POLR2G,[4] POLR2H,[4] POLR2A,[4] POLR2B,[4] POLR2L[4] and GTF2F2.[5]


  1. ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326. 
  2. ^ "Entrez Gene: POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa". 
  3. ^ Bertolotti, A; Melot T; Acker J; Vigneron M; Delattre O; Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. (UNITED STATES) 18 (3): 1489–97. ISSN 0270-7306. PMC 108863. PMID 9488465. 
  4. ^ a b c d e f Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (Jul 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. (UNITED STATES) 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 
  5. ^ Wei, W; Dorjsuren D; Lin Y; Qin W; Nomura T; Hayashi N; Murakami S (Apr 2001). "Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II". J. Biol. Chem. (United States) 276 (15): 12266–73. doi:10.1074/jbc.M009634200. ISSN 0021-9258. PMID 11278533. 

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