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Polymerase (RNA) II (DNA directed) polypeptide F
Protein POLR2F PDB 1qkl.png
PDB rendering based on 1qkl.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols POLR2F ; HRBP14.4; POLRF; RPABC14.4; RPABC2; RPB14.4; RPB6; RPC15
External IDs OMIM604414 MGI1349393 HomoloGene7178 GeneCards: POLR2F Gene
EC number
RNA expression pattern
PBB GE POLR2F 209511 at tn.png
More reference expression data
Species Human Mouse
Entrez 5435 69833
Ensembl ENSG00000100142 ENSMUSG00000033020
UniProt P61218 P61219
RefSeq (mRNA) NM_001301129 NM_027231
RefSeq (protein) NP_001288058 NP_081507
Location (UCSC) Chr 22:
38.35 – 38.44 Mb
Chr 15:
79.14 – 79.15 Mb
PubMed search [1] [2]

DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene.[1]

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.[2]


POLR2F has been shown to interact with POLR2C.[3]

See also[edit]


  1. ^ Pusch C, Wang Z, Roe B, Blin N (September 1996). "Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity". Genomics 34 (3): 440–2. doi:10.1006/geno.1996.0312. PMID 8786150. 
  2. ^ "Entrez Gene: POLR2F polymerase (RNA) II (DNA directed) polypeptide F". 
  3. ^ Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. (UNITED STATES) 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 

Further reading[edit]