POLR2J

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Polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
Identifiers
Symbols POLR2J ; POLR2J1; RPB11; RPB11A; RPB11m; hRPB14
External IDs OMIM604150 MGI109582 HomoloGene4542 GeneCards: POLR2J Gene
EC number 2.7.7.6
RNA expression pattern
PBB GE POLR2J 212782 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5439 20022
Ensembl ENSG00000005075 ENSMUSG00000039771
UniProt P52435 O08740
RefSeq (mRNA) NM_006234 NM_011293
RefSeq (protein) NP_006225 NP_035423
Location (UCSC) Chr 7:
102.11 – 102.12 Mb
Chr 5:
136.12 – 136.12 Mb
PubMed search [1] [2]

DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.[1]

Interactions[edit]

POLR2J has been shown to interact with POLR2C,[2][3] SATB1[4] and Apoptosis antagonizing transcription factor.[5]

References[edit]

  1. ^ "Entrez Gene: POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa". 
  2. ^ Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. (UNITED STATES) 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987. 
  3. ^ Corbi, Nicoletta; Di Padova Monica; De Angelis Roberta; Bruno Tiziana; Libri Valentina; Iezzi Simona; Floridi Aristide; Fanciulli Maurizio; Passananti Claudio (October 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. (United States) 16 (12): 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009. 
  4. ^ Durrin, Linda K; Krontiris Theodore G (June 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics (United States) 79 (6): 809–17. doi:10.1006/geno.2002.6772. ISSN 0888-7543. PMID 12036295. 
  5. ^ Fanciulli, M; Bruno T; Di Padova M; De Angelis R; Iezzi S; Iacobini C; Floridi A; Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J. (UNITED STATES) 14 (7): 904–12. ISSN 0892-6638. PMID 10783144. 

Further reading[edit]