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Polymerase (RNA) III (DNA directed) polypeptide C (62kD)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols POLR3C ; RPC3; RPC62
External IDs MGI1921664 HomoloGene38185 GeneCards: POLR3C Gene
RNA expression pattern
PBB GE POLR3C 209382 at tn.png
PBB GE POLR3C 210573 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10623 74414
Ensembl ENSG00000186141 ENSMUSG00000028099
UniProt Q9BUI4 Q9D483
RefSeq (mRNA) NM_006468 NM_028925
RefSeq (protein) NP_006459 NP_083201
Location (UCSC) Chr 1:
145.59 – 145.61 Mb
Chr 3:
96.71 – 96.73 Mb
PubMed search [1] [2]

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.[1][2][3]


POLR3C has been shown to interact with GTF3C4.[4][5]

Related gene problems[edit]


  1. ^ Wang Z, Roeder RG (Jun 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375. 
  2. ^ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170. 
  3. ^ "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)". 
  4. ^ Hsieh, Y J; Wang Z; Kovelman R; Roeder R G (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. (UNITED STATES) 19 (7): 4944–52. ISSN 0270-7306. PMC 84305. PMID 10373544. 
  5. ^ Hsieh, Y J; Kundu T K; Wang Z; Kovelman R; Roeder R G (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7697–704. ISSN 0270-7306. PMC 84812. PMID 10523658. 
  6. ^ Klopocki E, Schulze H, Strauss G et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129. 

Further reading[edit]