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Paraoxonase 3
Symbol PON3
External IDs OMIM602720 MGI106686 HomoloGene37371 GeneCards: PON3 Gene
EC number,,
RNA expression pattern
PBB GE PON3 213695 at tn.png
More reference expression data
Species Human Mouse
Entrez 5446 269823
Ensembl ENSG00000105852 ENSMUSG00000029759
UniProt Q15166 Q62087
RefSeq (mRNA) NM_000940 NM_173006
RefSeq (protein) NP_000931 NP_766594
Location (UCSC) Chr 7:
94.99 – 95.03 Mb
Chr 6:
5.22 – 5.26 Mb
PubMed search [1] [2]

Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.[1][2]


This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.[2]


  1. ^ Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009. 
  2. ^ a b "Entrez Gene: PON3 paraoxonase 3". 

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