POU2AF1

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POU class 2 associating factor 1
Protein POU2AF1 PDB 1cqt.png
PDB rendering based on 1cqt.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols POU2AF1 ; BOB1; OBF-1; OBF1; OCAB
External IDs OMIM601206 MGI105086 HomoloGene4543 GeneCards: POU2AF1 Gene
RNA expression pattern
PBB GE POU2AF1 205267 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5450 18985
Ensembl ENSG00000110777 ENSMUSG00000032053
UniProt Q16633 Q64693
RefSeq (mRNA) NM_006235 NM_011136
RefSeq (protein) NP_006226 NP_035266
Location (UCSC) Chr 11:
111.22 – 111.33 Mb
Chr 9:
51.21 – 51.24 Mb
PubMed search [1] [2]

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.[1][2]


Interactions[edit]

POU2AF1 has been shown to interact with POU2F1[3][4][5] and SIAH1.[6]

References[edit]

  1. ^ Junker S, Brondum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501. 
  2. ^ "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1". 
  3. ^ Chasman, D; Cepek K; Sharp P A; Pabo C O (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. (UNITED STATES) 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. ISSN 0890-9369. PMC 317104. PMID 10541551. 
  4. ^ Wong, M W; Henry R W; Ma B; Kobayashi R; Klages N; Matthias P; Strubin M; Hernandez N (Jan 1998). "The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1". Mol. Cell. Biol. (UNITED STATES) 18 (1): 368–77. ISSN 0270-7306. PMC 121507. PMID 9418884. 
  5. ^ Lee, L; Stollar E; Chang J; Grossmann J G; O'Brien R; Ladbury J; Carpenter B; Roberts S; Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry (United States) 40 (22): 6580–8. doi:10.1021/bi010095x. ISSN 0006-2960. PMID 11380252. 
  6. ^ Tiedt, R; Bartholdy B A; Matthias G; Newell J W; Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. (England) 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. ISSN 0261-4189. PMC 149178. PMID 11483517. 

Further reading[edit]