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POU class 2 associating factor 1
Protein POU2AF1 PDB 1cqt.png
PDB rendering based on 1cqt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols POU2AF1 ; BOB1; OBF-1; OBF1; OCAB
External IDs OMIM601206 MGI105086 HomoloGene4543 GeneCards: POU2AF1 Gene
RNA expression pattern
PBB GE POU2AF1 205267 at tn.png
More reference expression data
Species Human Mouse
Entrez 5450 18985
Ensembl ENSG00000110777 ENSMUSG00000032053
UniProt Q16633 Q64693
RefSeq (mRNA) NM_006235 NM_011136
RefSeq (protein) NP_006226 NP_035266
Location (UCSC) Chr 11:
111.22 – 111.33 Mb
Chr 9:
51.21 – 51.24 Mb
PubMed search [1] [2]

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.[1][2]


POU2AF1 has been shown to interact with POU2F1[3][4][5] and SIAH1.[6]


  1. ^ Junker S, Brondum-Nielsen K, Newell JW, Matthias P, Tommerup N (Jun 1996). "Assignment of the human gene for Oct-binding factor-1 (OBF1), a B-cell-specific coactivator of octamer-binding transcription factors 1 and 2, to 11q23.1 by somatic cell hybridization and in situ hybridization". Genomics 33 (1): 143–5. doi:10.1006/geno.1996.0173. PMID 8617501. 
  2. ^ "Entrez Gene: POU2AF1 POU domain, class 2, associating factor 1". 
  3. ^ Chasman, D; Cepek K; Sharp P A; Pabo C O (Oct 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. (UNITED STATES) 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. ISSN 0890-9369. PMC 317104. PMID 10541551. 
  4. ^ Wong, M W; Henry R W; Ma B; Kobayashi R; Klages N; Matthias P; Strubin M; Hernandez N (Jan 1998). "The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct-1". Mol. Cell. Biol. (UNITED STATES) 18 (1): 368–77. ISSN 0270-7306. PMC 121507. PMID 9418884. 
  5. ^ Lee, L; Stollar E; Chang J; Grossmann J G; O'Brien R; Ladbury J; Carpenter B; Roberts S; Luisi B (Jun 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry (United States) 40 (22): 6580–8. doi:10.1021/bi010095x. ISSN 0006-2960. PMID 11380252. 
  6. ^ Tiedt, R; Bartholdy B A; Matthias G; Newell J W; Matthias P (Aug 2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1". EMBO J. (England) 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. ISSN 0261-4189. PMC 149178. PMID 11483517. 

Further reading[edit]