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POU class 2 homeobox 1
Protein POU2F1 PDB 1cqt.png
PDB rendering based on 1cqt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols POU2F1 ; OCT1; OTF1; oct-1B
External IDs OMIM164175 MGI101898 HomoloGene37658 GeneCards: POU2F1 Gene
RNA expression pattern
PBB GE POU2F1 206789 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5451 18986
Ensembl ENSG00000143190 ENSMUSG00000026565
UniProt P14859 P25425
RefSeq (mRNA) NM_001198783 NM_011137
RefSeq (protein) NP_001185712 NP_035267
Location (UCSC) Chr 1:
167.19 – 167.4 Mb
Chr 1:
165.87 – 166 Mb
PubMed search [1] [2]

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.[1][2]


POU2F1 has been shown to interact with SNAPC4,[3][4] Ku80,[5][6] Glucocorticoid receptor,[7][8][9] Sp1 transcription factor,[10][11] NPAT,[12] POU2AF1,[4][13][14] Host cell factor C1,[15][16] TATA binding protein,[17] RELA,[18] Nuclear receptor co-repressor 2,[19] EPRS,[20] Glyceraldehyde 3-phosphate dehydrogenase,[12] MNAT1[21] and Retinoid X receptor alpha.[7][22]

See also[edit]


  1. ^ Roberts SB, Segil N, Heintz N (October 1991). "Differential phosphorylation of the transcription factor Oct1 during the cell cycle". Science 253 (5023): 1022–6. doi:10.1126/science.1887216. PMID 1887216. 
  2. ^ "Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1". 
  3. ^ Hovde, Stacy; Brooks Aimee; Strong Katie; Geiger James H (March 2002). "Crystallization of the October–1/SNAP190 peptide/DNA complex". Acta Crystallogr. D Biol. Crystallogr. (Denmark) 58 (Pt 3): 511–2. doi:10.1107/S0907444901021461. ISSN 0907-4449. PMID 11856838. 
  4. ^ a b Wong, M W; Henry R W; Ma B; Kobayashi R; Klages N; Matthias P; Strubin M; Hernandez N (January 1998). "The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with October–1". Mol. Cell. Biol. (UNITED STATES) 18 (1): 368–77. ISSN 0270-7306. PMC 121507. PMID 9418884. 
  5. ^ Schild-Poulter, C; Pope L; Giffin W; Kochan J C; Ngsee J K; Traykova-Andonova M; Haché R J (May 2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. (United States) 276 (20): 16848–56. doi:10.1074/jbc.M100768200. ISSN 0021-9258. PMID 11279128. 
  6. ^ Matheos, Diamanto; Ruiz Marcia T, Price Gerald B, Zannis-Hadjopoulos Maria (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta (Netherlands) 1578 (1–3): 59–72. doi:10.1016/S0167-4781(02)00497-9. ISSN 0006-3002. PMID 12393188. 
  7. ^ a b Préfontaine, G G; Walther R; Giffin W; Lemieux M E; Pope L; Haché R J (September 1999). "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter". J. Biol. Chem. (UNITED STATES) 274 (38): 26713–9. doi:10.1074/jbc.274.38.26713. ISSN 0021-9258. PMID 10480874. 
  8. ^ Wang, J M; Préfontaine G G; Lemieux M E; Pope L; Akimenko M A; Haché R J (October 1999). "Developmental Effects of Ectopic Expression of the Glucocorticoid Receptor DNA Binding Domain Are Alleviated by an Amino Acid Substitution That Interferes with Homeodomain Binding". Mol. Cell. Biol. (UNITED STATES) 19 (10): 7106–22. ISSN 0270-7306. PMC 84705. PMID 10490647. 
  9. ^ Préfontaine, G G; Lemieux M E; Giffin W; Schild-Poulter C; Pope L; LaCasse E; Walker P; Haché R J (June 1998). "Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3416–30. ISSN 0270-7306. PMC 108923. PMID 9584182. 
  10. ^ Ström, A C; Forsberg M; Lillhager P; Westin G (June 1996). "The transcription factors Sp1 and October–1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. (ENGLAND) 24 (11): 1981–6. doi:10.1093/nar/24.11.1981. ISSN 0305-1048. PMC 145891. PMID 8668525. 
  11. ^ Gunther, M; Laithier M; Brison O (July 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. (NETHERLANDS) 210 (1–2): 131–42. doi:10.1023/A:1007177623283. ISSN 0300-8177. PMID 10976766. 
  12. ^ a b Zheng, Lei; Roeder Robert G; Luo Yan (July 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell (United States) 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. ISSN 0092-8674. PMID 12887915. 
  13. ^ Chasman, D; Cepek K; Sharp P A; Pabo C O (October 1999). "Crystal structure of an OCA-B peptide bound to an October–1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. (UNITED STATES) 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. ISSN 0890-9369. PMC 317104. PMID 10541551. 
  14. ^ Lee, L; Stollar E; Chang J; Grossmann J G; O'Brien R; Ladbury J; Carpenter B; Roberts S; Luisi B (June 2001). "Expression of the October–1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry (United States) 40 (22): 6580–8. doi:10.1021/bi010095x. ISSN 0006-2960. PMID 11380252. 
  15. ^ La Boissière, S; Hughes T; O'Hare P (January 1999). "HCF-dependent nuclear import of VP16". EMBO J. (ENGLAND) 18 (2): 480–9. doi:10.1093/emboj/18.2.480. ISSN 0261-4189. PMC 1171141. PMID 9889203. 
  16. ^ Kristie, T M; Sharp P A (March 1993). "Purification of the cellular C1 factor required for the stable recognition of the October–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. (UNITED STATES) 268 (9): 6525–34. ISSN 0021-9258. PMID 8454622. 
  17. ^ Zwilling, S; Annweiler A; Wirth T (May 1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. (ENGLAND) 22 (9): 1655–62. doi:10.1093/nar/22.9.1655. ISSN 0305-1048. PMC 308045. PMID 8202368. 
  18. ^ van Heel, David A; Udalova Irina A, De Silva Arjuna P, McGovern Dermot P, Kinouchi Yoshitaka, Hull Jeremy, Lench Nicholas J, Cardon Lon R, Carey Alisoun H, Jewell Derek P, Kwiatkowski Dominic (May 2002). "Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors". Hum. Mol. Genet. (England) 11 (11): 1281–9. doi:10.1093/hmg/11.11.1281. ISSN 0964-6906. PMID 12019209. 
  19. ^ Kakizawa, T; Miyamoto T; Ichikawa K; Takeda T; Suzuki S; Mori J; Kumagai M; Yamashita K; Hashizume K (March 2001). "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor". J. Biol. Chem. (United States) 276 (13): 9720–5. doi:10.1074/jbc.M008531200. ISSN 0021-9258. PMID 11134019. 
  20. ^ Nie, J; Sakamoto S; Song D; Qu Z; Ota K; Taniguchi T (March 1998). "Interaction of October–1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. (NETHERLANDS) 424 (1–2): 27–32. doi:10.1016/S0014-5793(98)00131-8. ISSN 0014-5793. PMID 9537509. 
  21. ^ Inamoto, S; Segil N; Pan Z Q; Kimura M; Roeder R G (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. (UNITED STATES) 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. ISSN 0021-9258. PMID 9368058. 
  22. ^ Kakizawa, T; Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori J i, Kumagai M, Hashizume K (July 1999). "Functional interaction between October–1 and retinoid X receptor". J. Biol. Chem. (UNITED STATES) 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. ISSN 0021-9258. PMID 10383413. 

Further reading[edit]

External links[edit]