POU2F1

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POU class 2 homeobox 1
Protein POU2F1 PDB 1cqt.png
PDB rendering based on 1cqt.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols POU2F1 ; OCT1; OTF1; oct-1B
External IDs OMIM164175 MGI101898 HomoloGene37658 GeneCards: POU2F1 Gene
RNA expression pattern
PBB GE POU2F1 206789 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5451 18986
Ensembl ENSG00000143190 ENSMUSG00000026565
UniProt P14859 P25425
RefSeq (mRNA) NM_001198783 NM_011137
RefSeq (protein) NP_001185712 NP_035267
Location (UCSC) Chr 1:
167.19 – 167.4 Mb
Chr 1:
165.87 – 166 Mb
PubMed search [1] [2]

POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.[1][2]


Interactions[edit]

POU2F1 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ Roberts SB, Segil N, Heintz N (October 1991). "Differential phosphorylation of the transcription factor Oct1 during the cell cycle". Science 253 (5023): 1022–6. doi:10.1126/science.1887216. PMID 1887216. 
  2. ^ "Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1". 
  3. ^ Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T (March 1998). "Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1-2): 27–32. doi:10.1016/s0014-5793(98)00131-8. PMID 9537509. 
  4. ^ a b Préfontaine GG, Walther R, Giffin W, Lemieux ME, Pope L, Haché RJ (September 1999). "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter". J. Biol. Chem. 274 (38): 26713–9. doi:10.1074/jbc.274.38.26713. PMID 10480874. 
  5. ^ Wang JM, Préfontaine GG, Lemieux ME, Pope L, Akimenko MA, Haché RJ (October 1999). "Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding". Mol. Cell. Biol. 19 (10): 7106–22. PMC 84705. PMID 10490647. 
  6. ^ Préfontaine GG, Lemieux ME, Giffin W, Schild-Poulter C, Pope L, LaCasse E et al. (June 1998). "Recruitment of octamer transcription factors to DNA by glucocorticoid receptor". Mol. Cell. Biol. 18 (6): 3416–30. PMC 108923. PMID 9584182. 
  7. ^ a b McKnight S (July 2003). "Gene switching by metabolic enzymes--how did you get on the invitation list?". Cell 114 (2): 150–2. doi:10.1016/s0092-8674(03)00563-4. PMID 12887915. 
  8. ^ La Boissière S, Hughes T, O'Hare P (January 1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMC 1171141. PMID 9889203. 
  9. ^ Kristie TM, Sharp PA (March 1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622. 
  10. ^ Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M et al. (May 2001). "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. 276 (20): 16848–56. doi:10.1074/jbc.M100768200. PMID 11279128. 
  11. ^ Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta 1578 (1-3): 59–72. doi:10.1016/s0167-4781(02)00497-9. PMID 12393188. 
  12. ^ Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058. 
  13. ^ Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J et al. (March 2001). "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor". J. Biol. Chem. 276 (13): 9720–5. doi:10.1074/jbc.M008531200. PMID 11134019. 
  14. ^ a b Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P et al. (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. PMC 121507. PMID 9418884. 
  15. ^ Chasman D, Cepek K, Sharp PA, Pabo CO (October 1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551. 
  16. ^ Lee L, Stollar E, Chang J, Grossmann JG, O'Brien R, Ladbury J et al. (June 2001). "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry 40 (22): 6580–8. doi:10.1021/bi010095x. PMID 11380252. 
  17. ^ van Heel DA, Udalova IA, De Silva AP, McGovern DP, Kinouchi Y, Hull J et al. (May 2002). "Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors". Hum. Mol. Genet. 11 (11): 1281–9. doi:10.1093/hmg/11.11.1281. PMID 12019209. 
  18. ^ Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M et al. (July 1999). "Functional interaction between Oct-1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413. 
  19. ^ Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 3): 511–2. doi:10.1107/s0907444901021461. PMID 11856838. 
  20. ^ Ström AC, Forsberg M, Lillhager P, Westin G (June 1996). "The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. doi:10.1093/nar/24.11.1981. PMC 145891. PMID 8668525. 
  21. ^ Gunther M, Laithier M, Brison O (July 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. 210 (1-2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. 
  22. ^ Zwilling S, Annweiler A, Wirth T (May 1994). "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. doi:10.1093/nar/22.9.1655. PMC 308045. PMID 8202368. 

Further reading[edit]

External links[edit]