Amidophosphoribosyltransferase

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phosphoribosyl pyrophosphate amidotransferase
Identifiers
Symbol	PPAT
Entrez	5471
HUGO	9238
OMIM	172450
RefSeq	NM_002703
UniProt	Q06203
Other data
EC number	2.4.2.14
Locus	Chr. 4 pter-q21

Amidophosphoribosyltransferase (or phosphoribosyl pyrophosphate amidotransferase) is an enzyme that converts phosphoribosylpyrophosphate (PRPP) into 5-phosphoribosylamine. The enzyme uses the ammonia group from the glutamine side-chain. This is the committing step in de novo purine synthesis.

It is allosterically inhibited by AMP, GMP, and IMP.

PRPP	5-phosphoribosylamine

[edit] External links

• MeSH Amidophosphoribosyltransferase

This transferase article is a stub. You can help Wikipedia by expanding it. v • d • e

v • d • e Transferases: glycosyltransferases (EC 2.4) 2.4.1: Hexosyltransferases Glucosyltransferase Phosphorylase (Starch, Glycogen, Myo-) · Glycogen synthase · Debranching enzyme · Branching enzyme · 1,3-beta-glucan synthase · Ceramide glucosyltransferase Galactosyltransferase Lactose synthase · B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase · Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1) Glucuronosyltransferase B3GAT1, B3GAT2, B3GAT3 UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10 UGT2A1, UGT2A2, UGT2A3, UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28 Hyaluronan synthase: HAS1 · HAS2 · HAS3 Fucosyltransferase POFUT1 · POFUT2 · FUT1 · FUT2 · FUT3 · FUT4 · FUT5 · FUT6 · FUT7 · FUT8 · FUT9 · FUT10 · FUT11 Mannosyltransferase Dolichyl-phosphate-mannose-protein mannosyltransferase (POMT1, POMT2) 2.4.2: Pentosyltransferases Ribose ADP ribose Cholera toxin · Diphtheria toxin · Pertussis toxin · Poly ADP ribose polymerase Phosphoribosyltransferase Adenine phosphoribosyltransferase · Hypoxanthine-guanine phosphoribosyltransferase · Uracil phosphoribosyltransferase · Amidophosphoribosyltransferase Other Purine nucleoside phosphorylase Other Xylosyltransferase · Arabinosyltransferase (Indolylacetylinositol arabinosyltransferase) 2.4.99: Sialyltransferases Beta-galactoside alpha-2,6-sialyltransferase · Monosialoganglioside sialyltransferase

v • d • e Metabolism: amino acid metabolism - nucleotide enzymes Purine metabolism Anabolism R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase) Nucleotide salvage Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase Catabolism Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase Pyrimidine metabolism Anabolism CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase Catabolism Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1 Deoxyribonucleotides Ribonucleotide reductase - Nucleoside-diphosphate kinase - DCMP deaminase - Thymidylate synthase - Dihydrofolate reductase see also disorders, intermediates