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Protein phosphatase, EF-hand calcium binding domain 1
Symbols PPEF1 ; PP7; PPEF; PPP7C; PPP7CA
External IDs OMIM300109 MGI1097157 HomoloGene55960 GeneCards: PPEF1 Gene
EC number
RNA expression pattern
PBB GE PPEF1 206547 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5475 237178
Ensembl ENSG00000086717 ENSMUSG00000062168
UniProt O14829 O35655
RefSeq (mRNA) NM_006240 NM_011147
RefSeq (protein) NP_006231 NP_035277
Location (UCSC) Chr X:
18.69 – 18.85 Mb
Chr X:
160.62 – 160.74 Mb
PubMed search [1] [2]

Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene.[1][2][3]

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.[3]


PPEF1 has been shown to interact with Calmodulin 1.[4]


  1. ^ Montini E, Rugarli EI, Van de Vosse E, Andolfi G, Mariani M, Puca AA, Consalez GG, den Dunnen JT, Ballabio A, Franco B (Aug 1997). "A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin". Hum Mol Genet 6 (7): 1137–45. doi:10.1093/hmg/6.7.1137. PMID 9215685. 
  2. ^ Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J (Nov 1997). "Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C (rdgC)". Proc Natl Acad Sci U S A 94 (21): 11639–44. doi:10.1073/pnas.94.21.11639. PMC 23563. PMID 9326663. 
  3. ^ a b "Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1". 
  4. ^ Kutuzov, Mikhail A; Solov'eva Olga V, Andreeva Alexandra V, Bennett Nelly (May 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. (United States) 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. ISSN 0006-291X. PMID 12051765. 

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