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Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Symbol PPFIA4
External IDs OMIM603145 MGI1915757 HomoloGene66200 GeneCards: PPFIA4 Gene
RNA expression pattern
PBB GE PPFIA4 214978 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8497 68507
Ensembl ENSG00000143847 ENSMUSG00000026458
UniProt O75335 B8QI36
RefSeq (mRNA) NM_015053 NM_001144855.1
RefSeq (protein) NP_055868 NP_001138327.1
Location (UCSC) Chr 1:
203 – 203.05 Mb
Chr 1:
136.19 – 136.23 Mb
PubMed search [1] [2]

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.[1][2]


PPFIA4 has been shown to interact with ERC2,[3] GIT1[3][4] and Nuclear receptor coactivator 2.[5]


  1. ^ Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153. 
  2. ^ "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4". 
  3. ^ a b Ko, Jaewon; Na Moonseok; Kim Seho; Lee Jae-Ran; Kim Eunjoon (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. (United States) 278 (43): 42377–85. doi:10.1074/jbc.M307561200. ISSN 0021-9258. PMID 12923177. 
  4. ^ Ko, Jaewon; Kim Seho; Valtschanoff Juli G; Shin Hyewon; Lee Jae-Ran; Sheng Morgan; Premont Richard T; Weinberg Richard J; Kim Eunjoon (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. (United States) 23 (5): 1667–77. PMID 12629171. 
  5. ^ Wyszynski, Michael; Kim Eunjoon, Dunah Anthone W, Passafaro Maria, Valtschanoff Juli G, Serra-Pagès Carles, Streuli Michel, Weinberg Richard J, Sheng Morgan (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron (United States) 34 (1): 39–52. doi:10.1016/S0896-6273(02)00640-2. ISSN 0896-6273. PMID 11931740. 

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