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Peptidylprolyl isomerase (cyclophilin)-like 2
Protein PPIL2 PDB 1zkc.png
PDB rendering based on 1zkc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PPIL2 ; CYC4; CYP60; Cyp-60; UBOX7; hCyP-60
External IDs OMIM607588 MGI2447857 HomoloGene8643 GeneCards: PPIL2 Gene
EC number
RNA expression pattern
PBB GE PPIL2 206064 s at tn.png
PBB GE PPIL2 206063 x at tn.png
PBB GE PPIL2 209299 x at tn.png
More reference expression data
Species Human Mouse
Entrez 23759 66053
Ensembl ENSG00000100023 ENSMUSG00000022771
UniProt Q13356 Q9D787
RefSeq (mRNA) NM_014337 NM_001252444
RefSeq (protein) NP_055152 NP_001239373
Location (UCSC) Chr 22:
22.01 – 22.05 Mb
Chr 16:
17.09 – 17.11 Mb
PubMed search [1] [2]

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.[1][2]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ a b "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2". 

Further reading[edit]