Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13Bgene.
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
^Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID9872452.
Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.". Cell Death Differ.12 (4): 377–83. doi:10.1038/sj.cdd.4401575. PMID15706352.
Fogal V, Kartasheva NN, Trigiante G, et al. (2005). "ASPP1 and ASPP2 are new transcriptional targets of E2F.". Cell Death Differ.12 (4): 369–76. doi:10.1038/sj.cdd.4401562. PMID15731768.
Liu ZJ, Lu X, Zhang Y, et al. (2005). "Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53.". FEBS Lett.579 (7): 1587–90. doi:10.1016/j.febslet.2005.01.069. PMID15757645.
Bergamaschi D, Samuels Y, Zhong S, Lu X (2005). "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation.". Oncogene24 (23): 3836–41. doi:10.1038/sj.onc.1208535. PMID15782125.
Agirre X, Román-Gómez J, Jiménez-Velasco A, et al. (2006). "ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia.". Oncogene25 (13): 1862–70. doi:10.1038/sj.onc.1209236. PMID16314841.