PPP1R13B

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Protein phosphatase 1, regulatory subunit 13B
Identifiers
Symbols PPP1R13B ; ASPP1; p53BP2-like; p85
External IDs OMIM606455 MGI1336199 HomoloGene9090 GeneCards: PPP1R13B Gene
RNA expression pattern
PBB GE PPP1R13B 216347 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23368 21981
Ensembl ENSG00000088808 ENSMUSG00000021285
UniProt Q96KQ4 Q62415
RefSeq (mRNA) NM_015316 NM_011625
RefSeq (protein) NP_056131 NP_035755
Location (UCSC) Chr 14:
104.2 – 104.31 Mb
Chr 12:
111.83 – 111.91 Mb
PubMed search [1] [2]

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.[1][2]

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.[2]

References[edit]

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  2. ^ a b "Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B". 

Further reading[edit]