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Protein phosphatase 2, catalytic subunit, alpha isozyme
Protein PPP2CA PDB 2iae.png
PDB rendering based on 2iae.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PPP2CA ; PP2Ac; PP2CA; PP2Calpha; RP-C
External IDs OMIM176915 MGI1321159 HomoloGene37660 ChEMBL: 4703 GeneCards: PPP2CA Gene
EC number
RNA expression pattern
PBB GE PPP2CA 208652 at tn.png
More reference expression data
Species Human Mouse
Entrez 5515 19052
Ensembl ENSG00000113575 ENSMUSG00000020349
UniProt P67775 P63330
RefSeq (mRNA) NM_002715 NM_019411
RefSeq (protein) NP_002706 NP_062284
Location (UCSC) Chr 5:
134.19 – 134.23 Mb
Chr 11:
52.1 – 52.13 Mb
PubMed search [1] [2]

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.[1]

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.[2]


PPP2CA has been shown to interact with CCNG2,[3] CTTNBP2,[4] MOBKL3,[4] Bestrophin 1,[5] TLX1,[6] Bcl-2,[7] PPP2R3B,[4][8] Cyclin-dependent kinase 2,[9] STRN3,[4] Cyclin-dependent kinase 6,[9] IGBP1,[4][10][11][12] PPP2R5E,[4][13] STRN,[4] PPP2R5D,[4][13] PPP2R2A,[4][14] PPP2R1B,[4][15] PPP2R1A,[4][15] CTTNBP2NL,[4] FAM40A,[4] PPP2R5C,[4][13][16] PPP2R5B[4][13] and PPP2R5A.[4][13]

See also[edit]



  1. ^ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23→q31 and 8p12→p11.2, respectively". Cytogenet Cell Genet 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590. 
  2. ^ "Entrez Gene: PPP2CA protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform". 
  3. ^ Bennin, David A; Don Aruni S Arachchige, Brake Tiffany, McKenzie Jennifer L, Rosenbaum Heidi, Ortiz Linette, DePaoli-Roach Anna A, Horne Mary C (July 2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. (United States) 277 (30): 27449–67. doi:10.1074/jbc.M111693200. ISSN 0021-9258. PMID 11956189. 
  4. ^ a b c d e f g h i j k l m n o p Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. 
  5. ^ Marmorstein, Lihua Y; McLaughlin Precious J; Stanton J Brett; Yan Lin; Crabb John W; Marmorstein Alan D (August 2002). "Bestrophin interacts physically and functionally with protein phosphatase 2A". J. Biol. Chem. (United States) 277 (34): 30591–7. doi:10.1074/jbc.M204269200. ISSN 0021-9258. PMID 12058047. 
  6. ^ Kawabe, T; Muslin A J; Korsmeyer S J (January 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature (ENGLAND) 385 (6615): 454–8. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. 
  7. ^ Deng, X; Ito T; Carr B; Mumby M; May W S (December 1998). "Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A". J. Biol. Chem. (UNITED STATES) 273 (51): 34157–63. doi:10.1074/jbc.273.51.34157. ISSN 0021-9258. PMID 9852076. 
  8. ^ Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. ISSN 0270-7306. PMC 85219. PMID 10629059. 
  9. ^ a b Cheng, A; Kaldis P; Solomon M J (November 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". J. Biol. Chem. (UNITED STATES) 275 (44): 34744–9. doi:10.1074/jbc.M006210200. ISSN 0021-9258. PMID 10934208. 
  10. ^ Gingras, Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell Proteomics (United States) 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. ISSN 1535-9476. PMID 16085932. 
  11. ^ Chen, J; Peterson R T; Schreiber S L (June 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochem. Biophys. Res. Commun. (UNITED STATES) 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. ISSN 0006-291X. PMID 9647778. 
  12. ^ Chung, H; Nairn A C; Murata K; Brautigan D L (August 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry (UNITED STATES) 38 (32): 10371–6. doi:10.1021/bi990902g. ISSN 0006-2960. PMID 10441131. 
  13. ^ a b c d e McCright, B; Rivers A M; Audlin S; Virshup D M (September 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017. 
  14. ^ Kamibayashi, C; Lickteig R L; Estes R; Walter G; Mumby M C (October 1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. (UNITED STATES) 267 (30): 21864–72. ISSN 0021-9258. PMID 1328247. 
  15. ^ a b Zhou, Jin; Pham Huong T; Ruediger Ralf; Walter Gernot (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. (England) 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. ISSN 0264-6021. PMC 1223084. PMID 12370081. 
  16. ^ Ito, A; Kataoka T R; Watanabe M; Nishiyama K; Mazaki Y; Sabe H; Kitamura Y; Nojima H (February 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". EMBO J. (ENGLAND) 19 (4): 562–71. doi:10.1093/emboj/19.4.562. ISSN 0261-4189. PMC 305594. PMID 10675325. 

Further reading[edit]