PPP2R2C

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Protein phosphatase 2, regulatory subunit B, gamma
Identifiers
Symbols PPP2R2C ; B55-GAMMA; IMYPNO; IMYPNO1; PR52; PR55G
External IDs OMIM605997 MGI2442660 HomoloGene36386 ChEMBL: 2507 GeneCards: PPP2R2C Gene
EC number 3.1.3.16
Orthologs
Species Human Mouse
Entrez 5522 269643
Ensembl ENSG00000074211 ENSMUSG00000029120
UniProt Q9Y2T4 Q8BG02
RefSeq (mRNA) NM_001206994 NM_172994
RefSeq (protein) NP_001193923 NP_766582
Location (UCSC) Chr 4:
6.32 – 6.57 Mb
Chr 5:
36.87 – 36.96 Mb
PubMed search [1] [2]

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[1][2][3]

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References[edit]

  1. ^ Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Jan 2000). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Res 6 (5): 323–7. doi:10.1093/dnares/6.5.323. PMID 10574460. 
  2. ^ Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Nov 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics 67 (1): 83–6. doi:10.1006/geno.2000.6219. PMID 10945473. 
  3. ^ a b "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform". 

Further reading[edit]