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Protein phosphatase 2, regulatory subunit B', gamma
Protein PPP2R5C PDB 2iae.png
PDB rendering based on 2iae.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PPP2R5C ; B56G; PR61G
External IDs OMIM601645 MGI1349475 HomoloGene135298 GeneCards: PPP2R5C Gene
RNA expression pattern
PBB GE PPP2R5C 201877 s at tn.png
PBB GE PPP2R5C 213305 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5527 26931
Ensembl ENSG00000078304 ENSMUSG00000017843
UniProt Q13362 Q60996
RefSeq (mRNA) NM_001161725 NM_001037934.1
RefSeq (protein) NP_001155197 NP_001074926.1
Location (UCSC) Chr 14:
102.23 – 102.39 Mb
Chr 12:
111.69 – 111.82 Mb
PubMed search [1] [2]

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.[1][2]

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


PPP2R5C has been shown to interact with PPP2R1B[3] and PPP2CA.[3][4][5]


  1. ^ McCright B, Virshup DM (December 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". J Biol Chem 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815. 
  2. ^ a b "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform". 
  3. ^ a b McCright, B; Rivers A M; Audlin S; Virshup D M (September 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". J. Biol. Chem. (UNITED STATES) 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. ISSN 0021-9258. PMID 8703017. 
  4. ^ Ito, A; Kataoka T R; Watanabe M; Nishiyama K; Mazaki Y; Sabe H; Kitamura Y; Nojima H (February 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". EMBO J. (ENGLAND) 19 (4): 562–71. doi:10.1093/emboj/19.4.562. ISSN 0261-4189. PMC 305594. PMID 10675325. 
  5. ^ Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (January 2009). "A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. 

Further reading[edit]