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Protein phosphatase 3, regulatory subunit B, alpha
PBB Protein PPP3CA image.jpg
PDB rendering based on 1aui.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PPP3R1 ; CALNB1; CNB; CNB1
External IDs OMIM601302 MGI107172 HomoloGene68099 ChEMBL: 2082 GeneCards: PPP3R1 Gene
EC number
Species Human Mouse
Entrez 5534 19058
Ensembl ENSG00000221823 ENSMUSG00000033953
UniProt P63098 Q63810
RefSeq (mRNA) NM_000945 NM_024459
RefSeq (protein) NP_000936 NP_077779
Location (UCSC) Chr 2:
68.41 – 68.48 Mb
Chr 11:
17.16 – 17.2 Mb
PubMed search [1] [2]

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.[1][2][3]

Clinical significance[edit]

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.[4]


  1. ^ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet 72 (2-3): 236–41. doi:10.1159/000134198. PMID 8978785. 
  2. ^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868. 
  3. ^ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform". 
  4. ^ Cruchaga C, Kauwe JSK, Mayo K, Spiegel N, Bertelsen S et al. (2010). Myers, Amanda J., ed. "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLoS Genet 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329. 

Further reading[edit]