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Peroxisome proliferator-activated receptor gamma, coactivator-related 1
Symbols PPRC1 ; PRC
External IDs MGI2385096 HomoloGene9006 GeneCards: PPRC1 Gene
RNA expression pattern
PBB GE PPRC1 203737 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23082 226169
Ensembl ENSG00000148840 ENSMUSG00000055491
UniProt Q5VV67 Q6NZN1
RefSeq (mRNA) NM_001288727 NM_001081214
RefSeq (protein) NP_001275656 NP_001074683
Location (UCSC) Chr 10:
103.89 – 103.91 Mb
Chr 19:
46.04 – 46.07 Mb
PubMed search [1] [2]

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 is a protein that in humans is encoded by the PPRC1 gene.[1][2][3]

The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.[3]


PPRC1 has been shown to interact with USF2.[4]


  1. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581. 
  2. ^ Andersson U, Scarpulla RC (May 2001). "PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells". Mol Cell Biol 21 (11): 3738–49. doi:10.1128/MCB.21.11.3738-3749.2001. PMC 87014. PMID 11340167. 
  3. ^ a b "Entrez Gene: PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1". 
  4. ^ Moore, Meredith L; Park Edwards A; McMillin Jeanie B (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem. (United States) 278 (19): 17263–8. doi:10.1074/jbc.M210486200. ISSN 0021-9258. PMID 12611894. 

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