PRB1
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| Proline-rich protein BstNI subfamily 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PRB1; PM; PMF; PMS; PRB1L; PRB1M | ||||||||||||
| External IDs | OMIM: 180989 MGI: 2681872 HomoloGene: 74537 GeneCards: PRB1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5542 | 114600 | |||||||||||
| Ensembl | ENSG00000251655 | ENSMUSG00000067543 | |||||||||||
| UniProt | P02811 | n/a | |||||||||||
| RefSeq (mRNA) | NM_005039.3 | NM_053251.1 | |||||||||||
| RefSeq (protein) | NP_005030.2 | NP_444481.1 | |||||||||||
| Location (UCSC) | Chr 12: 11.5 – 11.55 Mb |
Chr 6: 132.08 – 132.18 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene.[1][2]
The protein encoded by this gene is a proline-rich salivary protein. This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal gland PRP, form a PRP gene cluster in the chromosomal 12p13 region. Alternatively spliced transcript variants encoding distinct isoforms have been described.[2]
[edit] References
- ^ Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet 53 (1): 264–78. PMC 1682219. PMID 8317492. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1682219.
- ^ a b "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5542.
[edit] Further reading
- Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. PMID 3055850.
- Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092.
- Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm)". Science 197 (4301): 378–9. doi:10.1126/science.877561. PMID 877561.
- Castle AM, Stahl LE, Castle JD (1992). "A 13-amino acid n-terminal domain of a basic proline-rich protein is necessary for storage in secretory granules and facilitates exit from the endoplasmic reticulum". J. Biol. Chem. 267 (18): 13093–100. PMID 1618808.
- Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics 120 (1): 267–78. PMC 1203497. PMID 2851479. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1203497.
- Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
- Kauffman D, Hofmann T, Bennick A, Keller P (1986). "Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6". Biochemistry 25 (9): 2387–92. doi:10.1021/bi00357a013. PMID 3521730.
- Azen E, Lyons KM, McGonigal T, et al. (1984). "Clones from the human gene complex coding for salivary proline-rich proteins". Proc. Natl. Acad. Sci. U.S.A. 81 (17): 5561–5. doi:10.1073/pnas.81.17.5561. PMC 391746. PMID 6089212. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=391746.
- Saitoh E, Isemura S, Sanada K (1984). "Further fractionation of basic proline-rich peptides from human parotid saliva and complete amino acid sequence of basic proline-rich peptide P-H". J. Biochem. 94 (6): 1991–9. PMID 6671974.
- Kauffman D, Wong R, Bennick A, Keller P (1983). "Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry 21 (25): 6558–62. doi:10.1021/bi00268a036. PMID 6924859.
- Isemura S, Saitoh E, Sanada K (1982). "Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E". J. Biochem. 91 (6): 2067–75. PMID 7118863.
- Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499.
- Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell 9 (3): 575–83. PMC 25286. PMID 9487127. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25286.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
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