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PRCP may also refer to the President of the Royal College of Physicians of London.
Prolylcarboxypeptidase (angiotensinase C)
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM176785 MGI1919711 HomoloGene55867 IUPHAR: 1584 ChEMBL: 2335 GeneCards: PRCP Gene
EC number
RNA expression pattern
PBB GE PRCP 201494 at tn.png
More reference expression data
Species Human Mouse
Entrez 5547 72461
Ensembl ENSG00000137509 ENSMUSG00000061119
UniProt P42785 Q7TMR0
RefSeq (mRNA) NM_005040 NM_028243
RefSeq (protein) NP_005031 NP_082519
Location (UCSC) Chr 11:
82.53 – 82.68 Mb
Chr 7:
92.88 – 92.93 Mb
PubMed search [1] [2]

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.[1][2]

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[2]


  1. ^ Tan F, Morris PW, Skidgel RA, Erdos EG (Sep 1993). "Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families". J Biol Chem 268 (22): 16631–8. PMID 8344943. 
  2. ^ a b "Entrez Gene: PRCP prolylcarboxypeptidase (angiotensinase C)". 

Further reading[edit]