PRDM1

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PR domain containing 1, with ZNF domain
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDM1 ; BLIMP1; PRDI-BF1
External IDs OMIM603423 MGI99655 HomoloGene925 GeneCards: PRDM1 Gene
RNA expression pattern
PBB GE PRDM1 217192 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 639 12142
Ensembl ENSG00000057657 ENSMUSG00000038151
UniProt O75626 Q60636
RefSeq (mRNA) NM_001198 NM_007548
RefSeq (protein) NP_001189 NP_031574
Location (UCSC) Chr 6:
106.53 – 106.56 Mb
Chr 10:
44.44 – 44.53 Mb
PubMed search [1] [2]

PR domain zinc finger protein 1 also known as BLIMP-1 is a protein that in humans is encoded by the PRDM1 gene.[1][2] BLIMP-1 acts as a repressor of beta-interferon (β-IFN) gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the β-IFN gene promoter. Transcription of this gene increases upon virus induction.[2]

Function[edit]

The increased expression of the Blimp-1 protein in B lymphocytes, T lymphocytes, NK cell and other key immune system effector cells leads to an immune response that is immediate and lasting, through proliferation and differentiation of antibody secreting plasma cells. In this setting among hematopoietic stem cells, Blimp-1 is considered a 'master regulator.'

The modular nature of Blimp-1 in the regulation of gene expression during B cell maturation was first reported by Dr. Mark Davis, et al. at Stanford:[3][4]

Second cancers after radiation treatment[edit]

A genome-wide association study has identified two genetic variations near the PRDM1 gene that predict an increased likelihood of developing a second cancer after radiation treatment for Hodgkin lymphoma.[5]

References[edit]

  1. ^ Keller AD, Maniatis T (Jun 1991). "Identification and characterization of a novel repressor of beta-interferon gene expression". Genes Dev 5 (5): 868–79. doi:10.1101/gad.5.5.868. PMID 1851123. 
  2. ^ a b "Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain". 
  3. ^ Turner CA, Mack DH, Davis MM (April 1994). "Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells". Cell 77 (2): 297–306. doi:10.1016/0092-8674(94)90321-2. PMID 8168136. 
  4. ^ Sciammas R, Davis MM (May 2004). "Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation". J. Immunol. 172 (9): 5427–40. doi:10.4049/jimmunol.172.9.5427. PMID 15100284. 
  5. ^ Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K (2011). "Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma". Nat. Med. 17 (8): 941–3. doi:10.1038/nm.2407. PMC 3229923. PMID 21785431. Lay summaryUniversity of Chicago Medical Center. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.