PR domain zinc finger protein 1 also known as BLIMP-1 is a protein that in humans is encoded by the PRDM1gene. BLIMP-1 acts as a repressor of beta-interferon (β-IFN) gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the β-IFN gene promoter. Transcription of this gene increases upon virus induction.
The increased expression of the Blimp-1 protein in B lymphocytes, T lymphocytes, NK cell and other key immune system effector cells leads to an immune response that is immediate and lasting, through proliferation and differentiation of antibody secreting plasma cells. In this setting among hematopoietic stem cells, Blimp-1 is considered a 'master regulator.'
The modular nature of Blimp-1 in the regulation of gene expression during B cell maturation was first reported by Dr. Mark Davis, et al. at Stanford:
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