PRDM2

PR domain containing 2, with ZNF domain
Rendering based on PDB 2JV0.
Available structures PDB 2JV0, 2QPW
Identifiers
Symbols	PRDM2; HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
External IDs	OMIM: 601196 MGI: 107628 HomoloGene: 40822 GeneCards: PRDM2 Gene
EC number	2.1.1.43
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • methyltransferase activity • zinc ion binding • transferase activity • histone-lysine N-methyltransferase activity • metal ion binding Cellular component • intracellular • nucleus • nucleus • Golgi apparatus Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • response to estradiol stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7799	110593
Ensembl	ENSG00000116731	ENSMUSG00000057637
UniProt	Q13029	n/a
RefSeq (mRNA)	NM_001007257.2	NM_001081355.3
RefSeq (protein)	NP_001007258.1	NP_001074824.3
Location (UCSC)	Chr 1: 14.03 – 14.15 Mb	Chr 4: 142.7 – 142.8 Mb
PubMed search	[1]	[2]

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha and Retinoblastoma protein.

Further reading

• Shapiro VS, Lee P, Winoto A (1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3.". Gene 163 (2): 329–30. doi:10.1016/0378-1119(95)00420-B. PMID 7590293. 
• Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene.". Eur. J. Biochem. 235 (3): 471–9. doi:10.1111/j.1432-1033.1996.00471.x. PMID 8654390. 
• Buyse IM, Takahashi EI, Huang S (1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36.". Genomics 34 (1): 119–21. doi:10.1006/geno.1996.0249. PMID 8661032. 
• Liu L, Shao G, Steele-Perkins G, Huang S (1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.". J. Biol. Chem. 272 (5): 2984–91. doi:10.1074/jbc.272.5.2984. PMID 9006946. 
• Xie M, Shao G, Buyse IM, Huang S (1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ.". J. Biol. Chem. 272 (42): 26360–6. doi:10.1074/jbc.272.42.26360. PMID 9334209. 
• He L, Yu JX, Liu L, et al. (1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.". Cancer Res. 58 (19): 4238–44. PMID 9766644. 
• Abbondanza C, Medici N, Nigro V, et al. (2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16204. 
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267. 
• Du Y, Carling T, Fang W, et al. (2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily.". Cancer Res. 61 (22): 8094–9. PMID 11719434. 
• Sasaki O, Meguro K, Tohmiya Y, et al. (2003). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia.". Tohoku J. Exp. Med. 196 (3): 193–201. doi:10.1620/tjem.196.193. PMID 12002276. 
• Poetsch M, Dittberner T, Woenckhaus C (2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36.". Oncogene 21 (19): 3038–42. doi:10.1038/sj.onc.1205457. PMID 12082534. 
• Sasaki O, Meguro K, Tohmiya Y, et al. (2003). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.". Br. J. Haematol. 119 (4): 940–8. doi:10.1046/j.1365-2141.2002.03972.x. PMID 12472571. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tokumaru Y, Nomoto S, Jerónimo C, et al. (2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer.". Oncogene 22 (44): 6954–8. doi:10.1038/sj.onc.1206403. PMID 14534544. 
• Kim KC, Geng L, Huang S (2004). "Inactivation of a histone methyltransferase by mutations in human cancers.". Cancer Res. 63 (22): 7619–23. PMID 14633678. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Pan KF, Lu YY, Liu WG, et al. (2004). "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability.". World J. Gastroenterol. 10 (18): 2719–22. PMID 15309726. 
• Rossi M, Abbondanza C, D'Arcangelo A, et al. (2004). "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation.". Cancer Lett. 215 (2): 229–37. doi:10.1016/j.canlet.2004.05.014. PMID 15488642. 
• Grundberg E, Carling T, Brändström H, et al. (2005). "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women.". J. Clin. Endocrinol. Metab. 89 (12): 6173–8. doi:10.1210/jc.2004-0403. PMID 15579774. 

External links

• MeSH PRDM2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.