PRDM9

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PR domain containing 9
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDM9 ; MEISETZ; MSBP3; PFM6; PRMD9; ZNF899
External IDs OMIM609760 MGI2384854 HomoloGene104139 GeneCards: PRDM9 Gene
EC number 2.1.1.43
Orthologs
Species Human Mouse
Entrez 56979 213389
Ensembl ENSG00000164256 ENSMUSG00000051977
UniProt Q9NQV7 Q96EQ9
RefSeq (mRNA) NM_020227 NM_144809
RefSeq (protein) NP_064612 NP_659058
Location (UCSC) Chr 5:
23.51 – 23.53 Mb
Chr 17:
15.54 – 15.56 Mb
PubMed search [1] [2]

PR domain[note 1] zinc finger protein 9 is a protein that in humans is encoded by the Prdm9 gene.[1] The protein has histone H3(K4) trimethyltransferase activity, a KRAB domain, and a DNA-binding domain consisting of multiple tandem C2H2 zinc finger (ZF) domains.[2] PRDM9 specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression, but does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation which plays a central role in the transcriptional activation of genes during early meiotic prophase.

Function[edit]

PRDM9 is thought to mediate the process of meiotic homologous recombination.[3]

Notes[edit]

  1. ^ positive-regulatory domain

References[edit]

  1. ^ "Entrez Gene: PR domain containing 9". 
  2. ^ Thomas JH, Emerson RO, Shendure J (2009). "Extraordinary molecular evolution in the PRDM9 fertility gene". PLoS ONE 4 (12): e8505. doi:10.1371/journal.pone.0008505. PMC 2794550. PMID 20041164. 
  3. ^ Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV (April 2011). "Genome-wide analysis reveals novel molecular features of mouse recombination hotspots". Nature 472 (7343): 375–8. doi:10.1038/nature09869. PMID 21460839. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.