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Peroxiredoxin 3
Protein PRDX3 PDB 1zye.png
PDB rendering based on 1zye.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRDX3 ; AOP-1; AOP1; HBC189; MER5; PRO1748; SP-22; prx-III
External IDs OMIM604769 MGI88034 HomoloGene4944 GeneCards: PRDX3 Gene
EC number
RNA expression pattern
PBB GE PRDX3 201619 at tn.png
More reference expression data
Species Human Mouse
Entrez 10935 11757
Ensembl ENSG00000165672 ENSMUSG00000024997
UniProt P30048 P20108
RefSeq (mRNA) NM_006793 NM_007452
RefSeq (protein) NP_006784 NP_031478
Location (UCSC) Chr 10:
120.93 – 120.94 Mb
Chr 19:
60.86 – 60.87 Mb
PubMed search [1] [2]

Thioredoxin-dependent peroxide reductase, mitochondrial is an enzyme that in humans is encoded by the PRDX3 gene.[1][2][3]

This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.[3]


PRDX3 has been shown to interact with MAP3K13.[4]


  1. ^ Tsuji K, Copeland NG, Jenkins NA, Obinata M (May 1995). "Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli". Biochem J 307 (2): 377–81. PMC 1136659. PMID 7733872. 
  2. ^ Watabe S, Hiroi T, Yamamoto Y, Fujioka Y, Hasegawa H, Yago N, Takahashi SY (Dec 1997). "SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria". Eur J Biochem 249 (1): 52–60. doi:10.1111/j.1432-1033.1997.t01-1-00052.x. PMID 9363753. 
  3. ^ a b "Entrez Gene: PRDX3 peroxiredoxin 3". 
  4. ^ Masaki, Megumi; Ikeda Atsushi; Shiraki Eriko; Oka Shogo; Kawasaki Toshisuke (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. (Germany) 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. ISSN 0014-2956. PMID 12492477. 

Further reading[edit]