This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
It has been demonstrated that serum peroxiredoxin 3 can be a valuable biomarker for the diagnosis and assessment of hepatocellular carcinoma It has been shown that peroxiredoxin proteins protect MCF-7 breast cancer cells against doxorubicin-mediated toxicity. Additionally, it has been shown that peroxiredoxin 3 is overexpressed in prostate cancer and promotes cancer cell survival by defending cells against the damages incurred by oxidative stress.
^Shi L, Wu LL, Yang JR, Chen XF, Zhang Y, Chen ZQ et al. (2014). "Serum peroxiredoxin3 is a useful biomarker for early diagnosis and assessemnt of prognosis of hepatocellular carcinoma in Chinese patients". Asian Pacific Journal of Cancer Prevention15 (7). PMID24815434.
^McDonald C, Muhlbauer J, Perlmutter G, Taparra K, Phelan SA (Jul 2014). "Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity". International Journal of Oncology45 (1). doi:10.3892/ijo.2014.2398. PMID24789097.
^Whitaker HC, Patel D, Howat WJ, Warren AY, Kay JD, Sangan T et al. (Aug 2013). "Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress". British Journal of Cancer109 (4). doi:10.1038/bjc.2013.396. PMID23880827.
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C et al. (1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID1286669.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Shih SF, Wu YH, Hung CH, Yang HY, Lin JY (2001). "Abrin triggers cell death by inactivating a thiol-specific antioxidant protein". J. Biol. Chem.276 (24): 21870–7. doi:10.1074/jbc.M100571200. PMID11285261.
Kim SH, Fountoulakis M, Cairns N, Lubec G (2001). "Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome". J. Neural Transm. Suppl. (61): 223–35. doi:10.1007/978-3-7091-6262-0_18. PMID11771746.
Rabilloud T, Heller M, Gasnier F, Luche S, Rey C, Aebersold R et al. (2002). "Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site". J. Biol. Chem.277 (22): 19396–401. doi:10.1074/jbc.M106585200. PMID11904290.
Choi JH, Kim TN, Kim S, Baek SH, Kim JH, Lee SR et al. (2003). "Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas". Anticancer Res.22 (6A): 3331–5. PMID12530083.
Krapfenbauer K, Engidawork E, Cairns N, Fountoulakis M, Lubec G (2003). "Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders". Brain Res.967 (1-2): 152–60. doi:10.1016/S0006-8993(02)04243-9. PMID12650976.
Chang TS, Cho CS, Park S, Yu S, Kang SW, Rhee SG (2004). "Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria". J. Biol. Chem.279 (40): 41975–84. doi:10.1074/jbc.M407707200. PMID15280382.
Liu L, Yang C, Yuan J, Chen X, Xu J, Wei Y et al. (2005). "RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains". Mol. Cells19 (1): 39–45. PMID15750338.