PRDX6

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Peroxiredoxin 6
Protein PRDX6 PDB 1prx.png
PDB rendering based on 1prx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRDX6 ; 1-Cys; AOP2; HEL-S-128m; NSGPx; PRX; aiPLA2; p29
External IDs OMIM602316 MGI894320 HomoloGene3606 GeneCards: PRDX6 Gene
EC number 1.11.1.15, 1.11.1.9
RNA expression pattern
PBB GE PRDX6 200845 s at tn.png
PBB GE PRDX6 200844 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9588 11758
Ensembl ENSG00000117592 ENSMUSG00000026701
UniProt P30041 O08709
RefSeq (mRNA) NM_004905 NM_007453
RefSeq (protein) NP_004896 NP_031479
Location (UCSC) Chr 1:
173.45 – 173.46 Mb
Chr 1:
161.24 – 161.25 Mb
PubMed search [1] [2]

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.[1][2]

Function[edit]

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.[2]

Model organisms[edit]

Model organisms have been used in the study of PRDX6 function. A conditional knockout mouse line, called Prdx6tm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[5]

References[edit]

  1. ^ Phelan SA (Mar 2001). "AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant". Antioxid Redox Signal 1 (4): 571–84. PMID 11233154. 
  2. ^ a b "Entrez Gene: PRDX6 peroxiredoxin 6". 
  3. ^ "Salmonella infection data for Prdx6". Wellcome Trust Sanger Institute. 
  4. ^ "Citrobacter infection data for Prdx6". Wellcome Trust Sanger Institute. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". 
  8. ^ "Mouse Genome Informatics". 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  10. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]