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Primase, DNA, polypeptide 2 (58kDa)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRIM2 ; PRIM2A; p58
External IDs OMIM176636 MGI97758 HomoloGene731 GeneCards: PRIM2 Gene
EC number 2.7.7.-
RNA expression pattern
PBB GE PRIM2A 205628 at tn.png
PBB GE PRIM2A 215708 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5558 19076
Ensembl ENSG00000146143 ENSMUSG00000026134
UniProt P49643 P33610
RefSeq (mRNA) NM_000947 NM_008922
RefSeq (protein) NP_000938 NP_032948
Location (UCSC) Chr 6:
57.18 – 57.51 Mb
Chr 1:
33.45 – 33.67 Mb
PubMed search [1] [2]

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[1][2]

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[2]


  1. ^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050. 
  2. ^ a b "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa". 

Further reading[edit]