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Protein kinase, AMP-activated, alpha 2 catalytic subunit
Protein PRKAA2 PDB 2h6d.png
PDB rendering based on 2h6d.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM600497 MGI1336173 HomoloGene4551 IUPHAR: 1542 ChEMBL: 2116 GeneCards: PRKAA2 Gene
EC number,,
RNA expression pattern
PBB GE PRKAA2 207709 at tn.png
More reference expression data
Species Human Mouse
Entrez 5563 108079
Ensembl ENSG00000162409 ENSMUSG00000028518
UniProt P54646 Q8BRK8
RefSeq (mRNA) NM_006252 NM_178143
RefSeq (protein) NP_006243 NP_835279
Location (UCSC) Chr 1:
57.11 – 57.18 Mb
Chr 4:
105.03 – 105.11 Mb
PubMed search [1] [2]

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.[1][2]


The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.[2]


  1. ^ Aguan K, Scott J, See CG, Sarkar NH (Dec 1994). "Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals". Gene 149 (2): 345–50. doi:10.1016/0378-1119(94)90174-0. PMID 7959015. 
  2. ^ a b "Entrez Gene: PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit". 

Further reading[edit]