PRKAG1

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Protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Protein PRKAG1 PDB 2uv4.png
PDB rendering based on 2uv4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRKAG1 ; AMPKG
External IDs OMIM602742 MGI108411 HomoloGene99712 ChEMBL: 2393 GeneCards: PRKAG1 Gene
RNA expression pattern
PBB GE PRKAG1 201805 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5571 19082
Ensembl ENSG00000181929 ENSMUSG00000067713
UniProt P54619 O54950
RefSeq (mRNA) NM_001206709 NM_016781
RefSeq (protein) NP_001193638 NP_058061
Location (UCSC) Chr 12:
49.4 – 49.41 Mb
Chr 15:
98.81 – 98.83 Mb
PubMed search [1] [2]

5'-AMP-activated protein kinase subunit gamma-1 is an enzyme that in humans is encoded by the PRKAG1 gene.[1][2][3]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[3]

Interactions[edit]

PRKAG1 has been shown to interact with PRKAB2[4] and PRKAB1.[4]

References[edit]

  1. ^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (February 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660. 
  2. ^ Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA (June 1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". J Biol Chem 271 (15): 8675–81. doi:10.1074/jbc.271.15.8675. PMID 8621499. 
  3. ^ a b "Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit". 
  4. ^ a b Cheung, P C; Salt I P; Davies S P; Hardie D G; Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. (ENGLAND). 346 Pt 3 (3): 659–69. doi:10.1042/0264-6021:3460659. ISSN 0264-6021. PMC 1220898. PMID 10698692. 

Further reading[edit]