PRKAG2

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Protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Identifiers
Symbols PRKAG2 ; AAKG; AAKG2; CMH6; H91620p; WPWS
External IDs OMIM602743 MGI1336153 HomoloGene136125 ChEMBL: 2453 GeneCards: PRKAG2 Gene
RNA expression pattern
PBB GE PRKAG2 218292 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51422 108099
Ensembl ENSG00000106617 ENSMUSG00000028944
UniProt Q9UGJ0 Q91WG5
RefSeq (mRNA) NM_001040633 NM_001170555
RefSeq (protein) NP_001035723 NP_001164026
Location (UCSC) Chr 7:
151.25 – 151.57 Mb
Chr 5:
24.86 – 25.1 Mb
PubMed search [1] [2]

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.[1][2][3]

Function[edit]

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four CBS domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interactions[edit]

PRKAG2 has been shown to interact with PRKAB2[4] and PRKAB1.[4]

References[edit]

  1. ^ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (February 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660. 
  2. ^ Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA (June 1996). "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". J Biol Chem 271 (15): 8675–81. doi:10.1074/jbc.271.15.8675. PMID 8621499. 
  3. ^ a b "Entrez Gene: PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit". 
  4. ^ a b Cheung, P C; Salt I P; Davies S P; Hardie D G; Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. (ENGLAND). 346 Pt 3: 659–69. doi:10.1042/0264-6021:3460659. ISSN 0264-6021. PMC 1220898. PMID 10698692. 

Further reading[edit]

External links[edit]