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Protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Symbols PRKAG3 ; AMPKG3
External IDs OMIM604976 MGI1891343 HomoloGene23006 GeneCards: PRKAG3 Gene
Species Human Mouse
Entrez 53632 241113
Ensembl ENSG00000115592 ENSMUSG00000006542
UniProt Q9UGI9 Q8BGM7
RefSeq (mRNA) NM_017431 NM_153744
RefSeq (protein) NP_059127 NP_714966
Location (UCSC) Chr 2:
219.69 – 219.7 Mb
Chr 1:
74.74 – 74.75 Mb
PubMed search [1] [2]

5'-AMP-activated protein kinase subunit gamma-3 is an enzyme that in humans is encoded by the PRKAG3 gene.[1][2]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.[2]


  1. ^ Milan D, Jeon JT, Looft C, Amarger V, Robic A, Thelander M, Rogel-Gaillard C, Paul S, Iannuccelli N, Rask L, Ronne H, Lundstrom K, Reinsch N, Gellin J, Kalm E, Roy PL, Chardon P, Andersson L (May 2000). "A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle". Science 288 (5469): 1248–51. doi:10.1126/science.288.5469.1248. PMID 10818001. 
  2. ^ a b "Entrez Gene: PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit". 

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