PRKCB1

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Protein kinase C, beta
Protein PRKCB1 PDB 1a25.png
PDB rendering based on 1a25.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRKCB ; PKC-beta; PKCB; PRKCB1; PRKCB2
External IDs OMIM176970 MGI97596 HomoloGene56424 ChEMBL: 3045 GeneCards: PRKCB Gene
EC number 2.7.11.13
Orthologs
Species Human Mouse
Entrez 5579 18751
Ensembl ENSG00000166501 ENSMUSG00000052889
UniProt P05771 P68404
RefSeq (mRNA) NM_002738 NM_008855
RefSeq (protein) NP_002729 NP_032881
Location (UCSC) Chr 16:
23.85 – 24.23 Mb
Chr 7:
122.29 – 122.63 Mb
PubMed search [1] [2]

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.[1]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2] This gene could be associated with autism[3] .[4]

Interactions[edit]

PRKCB1 has been shown to interact with RIPK4,[5] Beta adrenergic receptor kinase,[6] PDLIM5[7] and GNB2L1.[8]

References[edit]

  1. ^ Kubo K, Ohno S, Suzuki K (November 1987). "Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II". Nucleic Acids Res 15 (17): 7179–80. doi:10.1093/nar/15.17.7179. PMC 306204. PMID 3658678. 
  2. ^ "Entrez Gene: PRKCB1 protein kinase C, beta 1". 
  3. ^ Philippi, A; Roschmann, E; Tores, F; Lindenbaum, P; Benajou, A; Germain-Leclerc, L; Marcaillou, C; Fontaine, K et al. (October 2005). "Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism". Mol. Psychiatry 10 (10): 950–60. doi:10.1038/sj.mp.4001704. PMID 16027742. 
  4. ^ Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, S Puglisi-Allegra, K-L Reichelt, Persico AM (2009). "Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression". Mol Psychiatry 14 (7): 705–718. doi:10.1038/mp.2008.21. PMID 18317465. 
  5. ^ Chen, L; Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID 11278382. 
  6. ^ Yang, Xing-Long; Zhang Ya-Li, Lai Zhuo-Sheng, Xing Fei-Yue, Liu Yu-Hu (April 2003). "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase". World J. Gastroenterol. 9 (4): 800–3. PMID 12679936. 
  7. ^ Kuroda, S; Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill G N, Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095. 
  8. ^ Ron, D; Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (September 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. 274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. PMID 10480917. 

Further reading[edit]

  • Mochly-Rosen D (1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction". Science 268 (5208): 247–51. doi:10.1126/science.7716516. PMID 7716516. 
  • Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387. 
  • Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions". Chem. Phys. Lipids 116 (1–2): 75–91. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536. 

See also[edit]