Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCBgene.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. This gene could be associated with autism.
^Philippi, A; Roschmann, E; Tores, F; Lindenbaum, P; Benajou, A; Germain-Leclerc, L; Marcaillou, C; Fontaine, K et al. (October 2005). "Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism". Mol. Psychiatry10 (10): 950–60. doi:10.1038/sj.mp.4001704. PMID16027742.
^Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, S Puglisi-Allegra, K-L Reichelt, Persico AM (2009). "Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression". Mol Psychiatry14 (7): 705–718. doi:10.1038/mp.2008.21. PMID18317465.
^Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem.276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID11278382.
^Yang, Xing-Long; Zhang Ya-Li; Lai Zhuo-Sheng; Xing Fei-Yue; Liu Yu-Hu (April 2003). "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase". World J. Gastroenterol.9 (4): 800–3. PMID12679936.
^Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem.271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID8940095.
^Ron, D; Jiang Z; Yao L; Vagts A; Diamond I; Gordon A (September 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem.274 (38): 27039–46. doi:10.1074/jbc.274.38.27039. PMID10480917.