PRKCQ

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Protein kinase C, theta
Protein PRKCQ PDB 1xjd.png
PDB rendering based on 1xjd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRKCQ ; PRKCT; nPKC-theta
External IDs OMIM600448 MGI97601 HomoloGene21263 ChEMBL: 3920 GeneCards: PRKCQ Gene
EC number 2.7.11.13
RNA expression pattern
PBB GE PRKCQ 210039 s at tn.png
PBB GE PRKCQ 210038 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5588 18761
Ensembl ENSG00000065675 ENSMUSG00000026778
UniProt Q04759 Q02111
RefSeq (mRNA) NM_001242413 NM_008859
RefSeq (protein) NP_001229342 NP_032885
Location (UCSC) Chr 10:
6.47 – 6.62 Mb
Chr 2:
11.17 – 11.3 Mb
PubMed search [1] [2]

Protein kinase C theta (PKC-θ) is an enzyme that in humans is encoded by the PRKCQ gene.[1]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.[2]

Interactions[edit]

PRKCQ has been shown to interact with FYN,[3] GLRX3,[4] AKT1[5] and VAV1.[6]

PRKCQ has been shown to phosphorylate CARD11 as part of the NF-κB signaling pathway.[7]

See also[edit]

References[edit]

  1. ^ Baier G, Telford D, Giampa L, Coggeshall KM, Baier-Bitterlich G, Isakov N, Altman A (April 1993). "Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells". J Biol Chem 268 (7): 4997–5004. PMID 8444877. 
  2. ^ "Entrez Gene: PRKCQ protein kinase C, theta". 
  3. ^ Ron, D; Napolitano E W, Voronova A, Vasquez N J, Roberts D N, Calio B L, Caothien R H, Pettiford S M, Wellik S, Mandac J B, Kauvar L M (July 1999). "Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn". J. Biol. Chem. (UNITED STATES) 274 (27): 19003–10. doi:10.1074/jbc.274.27.19003. ISSN 0021-9258. PMID 10383400. 
  4. ^ Witte, S; Villalba M, Bi K, Liu Y, Isakov N, Altman A (January 2000). "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain". J. Biol. Chem. (UNITED STATES) 275 (3): 1902–9. doi:10.1074/jbc.275.3.1902. ISSN 0021-9258. PMID 10636891. 
  5. ^ Bauer, B; Krumböck N, Fresser F, Hochholdinger F, Spitaler M, Simm A, Uberall F, Schraven B, Baier G (August 2001). "Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells". J. Biol. Chem. (United States) 276 (34): 31627–34. doi:10.1074/jbc.M103098200. ISSN 0021-9258. PMID 11410591. 
  6. ^ Hehner, S P; Li-Weber M, Giaisi M, Dröge W, Krammer P H, Schmitz M L (April 2000). "Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells". J. Immunol. (UNITED STATES) 164 (7): 3829–36. doi:10.4049/jimmunol.164.7.3829. ISSN 0022-1767. PMID 10725744. 
  7. ^ Takeda, K; Harada Y, Watanabe R, Inutake Y, Ogawa S, Onuki K, Kagaya S, Tanabe K, Kishimoto H, Abe R (December 2008). "CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis.". Int. Immunol. 20 (12): 1507–15. doi:10.1093/intimm/dxn108. PMID 18829987. 

Further reading[edit]